3-(Piperidin-1-yl)phenol

Base Information

• Chemical Name: 3-(Piperidin-1-yl)phenol
• CAS No.: 27292-50-8
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Hs Code.: 2933399090
• European Community (EC) Number: 852-372-6
• NSC Number: 23894
• DSSTox Substance ID: DTXSID60282027
• Nikkaji Number: J32.665H
• Wikidata: Q82016189
• Mol file: 27292-50-8.mol

Synonyms:3-(piperidin-1-yl)phenol;27292-50-8;3-piperidinophenol;3-piperidin-1-ylphenol;NSC23894;3-hydroxyphenyl piperidine;SCHEMBL1263793;DTXSID60282027;YNLRDTBLEOQPQL-UHFFFAOYSA-N;MFCD00053001;NSC-23894;AKOS006227814;FS-3499;SB42988;CS-0019020;FT-0616363;EN300-7386368;Z1201618335

Chemical Property of 3-(Piperidin-1-yl)phenol

Chemical Property:

• Vapor Pressure: 4.84E-05mmHg at 25°C
• Melting Point: 123-124 °C
• Refractive Index: 1.575
• Boiling Point: 338.9 °C at 760 mmHg
• PKA: 10.37±0.10(Predicted)
• Flash Point: 183.6 °C
• PSA: 23.47000
• Density: 1.106 g/cm³
• LogP: 2.44750
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

99% ^*data from raw suppliers

3-(piperidin-1-yl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=CC(=CC=C2)O

Technology Process of 3-(Piperidin-1-yl)phenol

There total 17 articles about 3-(Piperidin-1-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3‐(piperidin‐1‐yl)aniline (27969-75-1) → 3-piperidinophenol (27292-50-8)

Guidance literature:

3‐(piperidin‐1‐yl)aniline; With sulfuric acid; In water; at 3 ℃; Green chemistry;

With sodium nitrite; In water; at 3 - 16 ℃; for 5h; Green chemistry;

With sulfuric acid; In water; at 85 ℃; for 0.00833333h; Green chemistry;

Reference yield: 90.0%

N-(3-methoxyphenyl)piperidine (32040-06-5) → 3-piperidinophenol (27292-50-8)

Guidance literature:

With boron tribromide; In dichloromethane; for 24h;

DOI:10.1021/jo00215a020

Reference yield: 88.0%

piperidine (110-89-4) + 3-Bromophenol (591-20-8) → 3-piperidinophenol (27292-50-8)

Guidance literature:

With lithium hexamethyldisilazane; 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane; palladium diacetate; In tetrahydrofuran; toluene; at 80 ℃; for 27h;

DOI:10.1002/adsc.200404005

upstream raw materials:

N-(3-methoxyphenyl)piperidine

piperidine

3-monochlorophenol

3-Bromophenol

Downstream raw materials:

2-nitroso-5-(piperidin-1-yl)phenol

1-(3-methoxy-4-nitrosophenyl)piperidine

Refernces

• 1、 -. "NEAR-INFRARED NERVE-SPARING FLUOROPHORES". Page/Page column 68. . Retrieved 2020/02/17.
• 2、 -. "Method for continuously synthesizing meta-di-alkane aminophenol". Paragraph 0030. . Retrieved 2019/01/23.