32040-06-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Piperidinoanisole is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new medications due to its unique chemical structure and biological activity.
Used in Agrochemical Production:
3-Piperidinoanisole is utilized as a building block in the creation of agrochemicals, playing a significant role in the formulation of products designed to protect crops and enhance agricultural yields.
Used in Specialty Chemicals:
3-Piperidinoanisole is employed as a versatile component in the production of specialty chemicals, where its specific properties are harnessed to meet the demands of various industrial applications.
Used in Research and Development:
3-Piperidinoanisole is used as a subject of study in research for its potential applications in treating various medical conditions, reflecting its importance in advancing scientific knowledge and healthcare solutions.

Upstream product

• 578-57-4 2-bromoanisole 
• 4442-11-9 lithium piperidide 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 111-24-0 1,5-dibromo-pentane 
• 536-90-3 m-Anisidine 
• 110-89-4 piperidine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 2398-37-0 3-methoxyphenyl bromide 
• 13716-12-6 tri-tert-butyl phosphine 
• 628-76-2 1,5-dichloropentane 
• 27292-50-8 3-piperidinophenol 
• 74-88-4 methyl iodide 
• 591-27-5 m-Hydroxyaniline 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 27292-50-8 3-piperidinophenol 
• 96649-01-3 2-methoxy-6-(1-piperidinyl)benzaldehyde 
• 88544-36-9 N-(5-methoxy-1,4-cyclohexadienyl)piperidine 
• 1032716-21-4 1-(3-methoxy-4-nitrosophenyl)piperidine 
• 88544-38-1 2-(1-piperidino-3-cyclohexenylidenemethyl)-3-ethylbenzothiazolium iodide 
• 88544-17-6 4-(1-piperidino-3-cyclohexenylidene)-3-methyl-1-phenyl-5-pyrazolone 
• 1398565-94-0 2-methoxy-6-piperidylphenyl(dicyclohexyl)phosphine 

Relevant academic research and scientific papers

Synthesis of N-heterocyclic carbene-Pd(II)-5-phenyloxazole complexes and initial studies of their catalytic activity toward the Buchwald-Hartwig amination of aryl chlorides

Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand have been obtained in moderate to good yields by a one-pot reaction of the corresponding imidazolium salts, palladium chloride and 5-phenyloxazole under mild conditions. Initial studies showed that one of the complexes is an efficient catalyst for the Buchwald-Hartwig amination of aryl chlorides with various secondary and primary amines under the varied catalyst loading of 0.01-0.05 mol%, thus it will enrich the chemistry of NHCs and give an alternative catalyst for the coupling of challenging while cost-low aryl chlorides.

NEAR-INFRARED NERVE-SPARING FLUOROPHORES

Provided are far red to near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.

NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION

Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.

Regiospecific N-Arylation of Aliphatic Amines under Mild and Metal-Free Reaction Conditions

A transition metal-free N-arylation of primary and secondary amines with diaryliodonium salts is presented. Both acyclic and cyclic amines are well tolerated, providing a large set of N-alkyl anilines. The methodology is unprecedented among metal-free methods in terms of amine scope, the ability to transfer both electron-withdrawing and electron-donating aryl groups, and efficient use of resources, as excess substrate or reagents are not required.

N-Heterocyclic carbene-palladacyclic complexes: synthesis, characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01 mol%).

Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.

Discovery of N-(Naphthalen-1-yl)-N′-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers

A class of N-(naphthalen-1-yl)-N′-alkyl oxalamides have been proven to be powerful ligands, making a coupling reaction of (hetero)aryl iodides with primary amines proceed at 50 °C with only 0.01 mol % of Cu2O and ligand as well as a coupling reaction of (hetero)aryl bromides with primary amines and ammonia at 80 °C with only 0.1 mol % of Cu2O and ligand. A wide range of coupling partners work well under these conditions, thereby providing an easy to operate method for preparing (hetero)aryl amines.

n-Butyllithium-mediated synthesis of N-aryl tertiary amines by reactions of fluoroarenes with secondary amines at room temperature

A simple and facile method for the synthesis of aromatic tertiary amines by amination of fluoroarenes with secondary amines in the presence of n-butyllithium at room temperature was reported.

Synthesis of N-heterocyclic carbene-Pd(II) complexes and their catalytic activity in the Buchwald-Hartwig amination of aryl chlorides

Novel N-heterocyclic carbene-palladium(II) complexes using 2-picolinic acid as the ancillary ligand have been successfully developed under mild conditions. Their catalytic activity in organic synthesis has been initially tested in the Buchwald-Hartwig amination of secondary and primary amines with aryl chlorides. Various substituents on both substrates can be tolerated, giving the desired coupling products in good to almost quantitative yields. The minimum catalyst loading can be 0.01 mol%, implying their potential application toward industrial processes.

N-heterocyclic carbene-palladium complex, and preparation method and application thereof

The invention discloses an N-heterocyclic carbene-palladium complex, and a preparation method and application thereof. The N-heterocyclic carbene-palladium complex disclosed by the invention is shown in Formula (I), wherein L1 is a quinoline ligand or isoquinoline ligand, and N in the L1 is connected with Pd; L2 is an N-heterocyclic carbene ligand, and carbene carbon in the L2 is connected with the Pd; and X1 and X2 are respectively independently an anionic ligand. The N-heterocyclic carbene-palladium complex disclosed by the invention can efficiently catalyze carbon-carbon or carbon-heteroatom coupling reaction using aryl halide as a substrate. The formula is shown in the specification.