Cyclopropanecarboxylic acid, 4-nitrophenyl ester

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 4-nitrophenyl ester
• CAS No.: 26050-99-7
• Molecular Formula: C10H9NO4
• Molecular Weight: 207.186
• Mol file: 26050-99-7.mol

Synonyms:

Chemical Property of Cyclopropanecarboxylic acid, 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxylic acid, 4-nitrophenyl ester

There total 10 articles about Cyclopropanecarboxylic acid, 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.7%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + cyclopropanecarboxylic acid (1759-53-1) → p-nitrophenyl cyclopropanecarboxylate (26050-99-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃; for 8h;

DOI:10.1016/j.molcatb.2011.07.010

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → p-nitrophenyl cyclopropanecarboxylate (26050-99-7)

Guidance literature:

Multi-step reaction with 13 steps

1: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

2: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

3: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

4: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

5: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

6: Bacillus subtilis 168 SrfAD esterase / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

7: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

8: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

9: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

10: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

11: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

12: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

13: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

With dmap; Candida antarctica lipase B; Bacillus subtilis 168 SrfAD esterase; dicyclohexyl-carbodiimide; In dimethyl sulfoxide;

DOI:10.1016/j.molcatb.2011.07.010

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + cyclopropanecarboxylic acid chloride (4023-34-1) → p-nitrophenyl cyclopropanecarboxylate (26050-99-7)

Guidance literature:

DOI:10.1039/a801540f

upstream raw materials:

4-nitro-phenol

cyclopropanecarboxylic acid chloride

cyclopropanecarboxylic acid

4-nitrophenyl 4-methylpentanoate

Downstream raw materials:

benzylamine; 4-nitro-phenolate

cyclopropanecarboxylic acid benzylamide

methyl 1-[4-(acetylamino)phenyl]cyclopropanecarboxylate

4-nitro-phenol