Ro28-2653

Base Information

Chemical Name:Ro28-2653
CAS No.:261956-22-3
Molecular Formula:C26H23N5O5
Molecular Weight:485.49100
Hs Code.:
Mol file:261956-22-3.mol

Synonyms:5-[1,1'-Biphenyl]-4-yl-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione;2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[1,1'-biphenyl]-4-yl-5-[4-(4-nitrophenyl)-1-piperazinyl]-;

Suppliers and Price of Ro28-2653

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RO28-2653
250mg
$ 1320.00

American Custom Chemicals Corporation
RO-282653 95.00%
5MG
$ 500.45

Total 11 raw suppliers

Chemical Property of Ro28-2653

Chemical Property:

PKA:7.29±0.10(Predicted)
PSA：127.57000
Density:1.370±0.06 g/cm3(Predicted)
LogP:3.82900

Purity/Quality:

99%, ^*data from raw suppliers

RO28-2653 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses RO 28-2653 exhibits anti-invasive, antitumoral, and antiangiogenic efficacy and is also classified as an orally active and selective matrix metalloproteinases inhibitor.

Technology Process of Ro28-2653

There total 5 articles about Ro28-2653 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 877475-79-1
5-[1,1'-biphenyl]-4-yl-5-bromopyrimidine-2,4,6(1H,3H,5H)-trione

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 261956-22-3
5-biphenyl-4-yl-5-[4-(4-nitro-phenyl)-piperazin-1-yl]pyrimidine-2,4,6-trione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Cooling;
DOI:10.1021/op049965j

Reference yield:

: 59793-29-2
methyl 2-(1,1'-biphenyl-4-yl)acetate

: 261956-22-3
5-biphenyl-4-yl-5-[4-(4-nitro-phenyl)-piperazin-1-yl]pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 1 h / 60 °C

2: potassium tert-butylate / tetrahydrofuran / 6 h / 80 °C

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.27 h / 3 - 10 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling

With N-Bromosuccinimide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/op049965j

Reference yield:

: 156140-46-4
dimethyl (4-biphenyl)malonate

: 261956-22-3
5-biphenyl-4-yl-5-[4-(4-nitro-phenyl)-piperazin-1-yl]pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 6 h / 80 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.27 h / 3 - 10 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling

With N-Bromosuccinimide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/op049965j