877475-79-1

Upstream product

• 5728-52-9 (4-biphenylyl)acetic acid 
• 59793-29-2 methyl 2-(1,1'-biphenyl-4-yl)acetate 
• 156140-46-4 dimethyl (4-biphenyl)malonate 

Downstream Products

• 261956-22-3 5-biphenyl-4-yl-5-[4-(4-nitro-phenyl)-piperazin-1-yl]pyrimidine-2,4,6-trione 
• 877475-78-0 5-[4-(4-aminophenyl)piperazin-1-yl]-5-[1,1'-biphenyl]-4-ylpyrimidine-2,4,6(1H,3H,5H)-trione 

Relevant academic research and scientific papers

An improved synthesis of the selective matrix metalloproteinase inhibitor, Ro 28-2653

An efficient synthesis of Ro 28-2653, a selective matrix metalloproteinase inhibitor, has been developed. The title compound was prepared in four steps and 76% overall yield from 4-biphenylacetic acid. The key, barbituric acid formation step was significantly improved by using 2-propanol and potassium tert-butoxide as the solvent and base, respectively, instead of the typical ethanol and sodium ethoxide combination.