Nipecotic acid

Base Information

• Chemical Name: Nipecotic acid
• CAS No.: 262853-93-0
• Molecular Formula: C6H11NO2
• Mol file: 262853-93-0.mol

Synonyms:

Chemical Property of Nipecotic acid

Chemical Property:

• Vapor Pressure: 0.0026mmHg at 25°C

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:

MSDS Files:

Useful:

Technology Process of Nipecotic acid

There total 52 articles about Nipecotic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

guvacine (498-96-4) → (R)-nipecotic acid (498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0)

Guidance literature:

With C₆₃H₇₈IrNOP⁽²⁺⁾*C₃₂H₁₂BF₂₄^(1-); hydrogen; In methanol; at 60 ℃; for 12h; under 4560.31 Torr; enantioselective reaction; Autoclave;

DOI:10.1002/anie.201301341

Reference yield:

Piperidine-3-carboxylic acid 4-nitro-phenyl ester (119228-39-6) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + nipecotic acid (498-95-3,262853-93-0)

Guidance literature:

With water; at 37 ℃; pH 7.4; other nipecotic acid phenyl esters; various solutions;

DOI:10.1002/jps.2600790115

Reference yield:

Piperidine-3-carboxylic acid 4-nitro-phenyl ester; hydrobromide → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + nipecotic acid (498-95-3,262853-93-0)

Guidance literature:

With Cu complex of polymer from 2,6-bis-aminomethylpyridine and 4,4'-bis-aminomethyldiphenylmethane; water; In dimethyl sulfoxide; at 25 ℃; Rate constant; var.reag.: Cu⁽²⁺⁾ complex of 2,6-bis-benzylaminomethylpyridine; oligomers of 2,6-bis-aminomethylpyridine and 4,4'-bis-aminomethyldiphenylmethane;

DOI:10.1002/(sici)1099-0690(199806)1998:6<1143::aid-ejoc1143>3.0.co;2-u

upstream raw materials:

nicotinic acid

Pyridine-2,3-dicarboxylic acid

3-methoxycarbonylpiperidine

piperidine

Downstream raw materials:

methyl piperidine-3-carboxylate hydrochloride

N-(tert-butyloxycarbonyl)nipecotic acid

3-methoxycarbonylpiperidine

1-[3-(3-cyano-phenyl)-2-(2,4,6-triisopropyl-benzenesulfonylamino)-propionyl]-piperidine-3-carboxylic acid

Refernces

• 1、 Zhu, Chendan,Mandrelli, Francesca,Zhou, Hui,Maji, Rajat,List, Benjamin. "Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids". . p. 3312 - 3317. Retrieved 2021/04/07.
• 2、 -. "AN ECO-FRIENDLY PROCESS FOR HYDROGENATION OR/AND HYDRODEOXYGENATION OF ORGANIC COMPOUND USING HYDROUS RUTHENIUM OXIDE CATALYST". Page/Page column 15; 22. . Retrieved 2017/08/01.