(2E)-5-Phenyl-2-pentenoic acid methyl ester

Base Information

• Chemical Name: (2E)-5-Phenyl-2-pentenoic acid methyl ester
• CAS No.: 26429-97-0
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol file: 26429-97-0.mol

Synonyms:(E)-methyl 5-phenyl-pent-2-enoate;methyl (E)-5-phenyl-2-pentenoate;methyl trans-5-phenyl-2-pentenoate;5-phenyl-2(E)-pentenoic acid methyl ester;(E)-5-Phenyl-pent-2-enoic acid methyl ester;methyl 5-phenylpent-2-enoate;(E)-5-phenyl-2-pentenoic acid methyl ester;

Chemical Property of (2E)-5-Phenyl-2-pentenoic acid methyl ester

Chemical Property:

• Boiling Point: 129 °C (0.3 mmHg)
• PSA: 26.30000
• LogP: 2.34840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-5-Phenyl-2-pentenoic acid methyl ester

There total 35 articles about (2E)-5-Phenyl-2-pentenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-phenyl-propionaldehyde (104-53-0) + dichloroacetic acid methyl ester (116-54-1) → methyl (2E)-5-phenyl-2-pentenoate (26429-97-0)

Guidance literature:

With chromium dichloride; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2004.05.113

Reference yield: 95.0%

3-phenyl-propionaldehyde (104-53-0) + methoxycarbonylmethyltriphenylphosphonium benzoate → methyl (2E)-5-phenyl-2-pentenoate (26429-97-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(00)00706-7

Reference yield: 92.0%

3-phenyl-propionaldehyde (104-53-0) + methoxycarbonylmethyltriphenylphosphonium formate → methyl (2E)-5-phenyl-2-pentenoate (26429-97-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(00)00903-0

upstream raw materials:

3-phenyl-propionaldehyde

Methyl diethylphosphonoacetate

trimethyl phosphonoacetate

methyl 5-phenyl-2-(2'-thiopyridyl)pentanoate

Downstream raw materials:

(E)-5-phenyl-2-penten-1-ol

3,4-Diphenethyl-hexanedioic acid dimethyl ester

methyl (2R,3S)-3-(2-phenylethyl)oxiranecarboxylate

3-Phenethyl-pentanedioic acid monomethyl ester

Refernces

• 1、 Palanivel, Ashokkumar,Mubeen, Sidra,Warner, Thomas,Ahmed, Nayeem,Clive, Derrick L. J.. "Formation of Enol Ethers by Radical Decarboxylation of α-Alkoxy β-Phenylthio Acids". . p. 12542 - 12552. Retrieved 2019/10/19.
• 2、 Yang, Xinkan,Tsui, Gavin Chit. "Trifluoromethylation of Unactivated Alkenes with Me3SiCF3 and N-Iodosuccinimide". supporting information. p. 1521 - 1525. Retrieved 2019/03/07.