Ethyl 2-methyl-4-(trifluoromethyl)furan-3-carboxylate

Base Information

Chemical Name:Ethyl 2-methyl-4-(trifluoromethyl)furan-3-carboxylate
CAS No.:26431-52-7
Molecular Formula:C9H9F3O3
Molecular Weight:222.16100
Hs Code.:2932190090
DSSTox Substance ID:DTXSID20475736
Nikkaji Number:J1.665.888J
Wikidata:Q82306489
Mol file:26431-52-7.mol

Synonyms:26431-52-7;ETHYL 2-METHYL-4-(TRIFLUOROMETHYL)FURAN-3-CARBOXYLATE;3-Furancarboxylic acid, 2-methyl-4-(trifluoromethyl)-, ethyl ester;SCHEMBL9223224;DTXSID20475736;BBA43152;MFCD18633627;AKOS025213850;AS-36674;CS-0216147;EN300-344283;Ethyl 2-methyl-4-trifluoromethyl-3-furancarboxylate;ETHYL2-METHYL-4-(TRIFLUOROMETHYL)FURAN-3-CARBOXYLATE

Suppliers and Price of Ethyl 2-methyl-4-(trifluoromethyl)furan-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl2-methyl-4-(trifluoromethyl)furan-3-carboxylate 97%
1g
$ 434.00

Alichem
Ethyl2-methyl-4-(trifluoromethyl)furan-3-carboxylate
1g
$ 878.01

Alichem
Ethyl2-methyl-4-(trifluoromethyl)furan-3-carboxylate
250mg
$ 312.84

Total 7 raw suppliers

Chemical Property of Ethyl 2-methyl-4-(trifluoromethyl)furan-3-carboxylate

Chemical Property:

Boiling Point:216.1±40.0 °C(Predicted)
PSA：39.44000
Density:1.259±0.06 g/cm3(Predicted)
LogP:2.78350
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:222.05037863
Heavy Atom Count:15
Complexity:239

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-methyl-4-(trifluoromethyl)furan-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(OC=C1C(F)(F)F)C

Technology Process of Ethyl 2-methyl-4-(trifluoromethyl)furan-3-carboxylate

There total 4 articles about Ethyl 2-methyl-4-(trifluoromethyl)furan-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 430424-55-8
(E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester

: 26431-52-7
ethyl 2-methyl-4-(trifluoromethyl)-3-furoate

Guidance literature:: In decalin; for 3h; Heating;
DOI:10.1016/S0040-4039(01)02230-4

Reference yield: 31.0%

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 141-97-9
ethyl acetoacetate

: 26431-52-7
ethyl 2-methyl-4-(trifluoromethyl)-3-furoate

Guidance literature:: 3-bromo-1,1,1-trifluoroacetone; ethyl acetoacetate; With sodium ethanolate; In ethanol; at 0 - 20 ℃; for 16h;

With toluene-4-sulfonic acid; In toluene; for 4h; Reflux;

Reference yield:

: 141-97-9
ethyl acetoacetate

: 26431-52-7
ethyl 2-methyl-4-(trifluoromethyl)-3-furoate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NaH / tetrahydrofuran / 6 h / 60 °C

2: 81 percent / decahydronaphthalene / 3 h / Heating

With sodium hydride; In tetrahydrofuran; decalin; 1: Michael addition;
DOI:10.1016/S0040-4039(01)02230-4