(E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester

Base Information

• Chemical Name: (E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester
• CAS No.: 430424-55-8
• Molecular Formula: C₁₅H₁₅F₃O₃S
• Molecular Weight: 332.344
• Mol file: 430424-55-8.mol

Synonyms:(E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester

Chemical Property of (E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester

There total 1 articles about (E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl acetoacetate (141-97-9) + 1-Bromo-1-phenylsulfanyl-3,3,3-trifluoroprop-1-ene (177272-50-3) → (E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester (430424-55-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 60 ℃; for 6h;

DOI:10.1016/S0040-4039(01)02230-4

Reference yield: 100.0%

(E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester (430424-55-8) → (E)-5-Phenylsulfanyl-4-trifluoromethyl-pent-4-en-2-one

Guidance literature:

With sodium acetate; p-benzoquinone; In acetic acid; at 100 ℃; for 24h;

DOI:10.1016/S0040-4039(01)02230-4

Reference yield: 81.0%

(E)-3-Hydroxy-2-((E)-2-phenylsulfanyl-1-trifluoromethyl-vinyl)-but-2-enoic acid ethyl ester (430424-55-8) → ethyl 2-methyl-4-(trifluoromethyl)-3-furoate (26431-52-7)

Guidance literature:

In decalin; for 3h; Heating;

DOI:10.1016/S0040-4039(01)02230-4

upstream raw materials:

ethyl acetoacetate

1-Bromo-1-phenylsulfanyl-3,3,3-trifluoroprop-1-ene

Downstream raw materials:

ethyl 2-methyl-4-(trifluoromethyl)-3-furoate