2-Propanol, 1-(diphenylphosphino)-

Base Information

• Chemical Name: 2-Propanol, 1-(diphenylphosphino)-
• CAS No.: 2652-63-3
• Molecular Formula: C15H17OP
• Molecular Weight: 244.273
• DSSTox Substance ID: DTXSID60385188
• Nikkaji Number: J1.946.829A
• Mol file: 2652-63-3.mol

Synonyms:2-Propanol, 1-(diphenylphosphino)-;2652-63-3;SCHEMBL3297250;DTXSID60385188;1-(Diphenylphosphino)-2-propanol;HMS1578K09

Chemical Property of 2-Propanol, 1-(diphenylphosphino)-

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 244.101702159
• Heavy Atom Count: 17
• Complexity: 189

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CP(C1=CC=CC=C1)C2=CC=CC=C2)O

Technology Process of 2-Propanol, 1-(diphenylphosphino)-

There total 6 articles about 2-Propanol, 1-(diphenylphosphino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

diphenylphosphane (829-85-6) + methyloxirane (75-56-9,16033-71-9) → 1-diphenylphosphanylpropan-2-ol (2652-63-3)

Guidance literature:

With cesium hydroxide; 4 A molecular sieve; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2003.08.068

Reference yield:

diphenylphosphane (829-85-6) + methyloxirane (75-56-9,16033-71-9) → 1-(diphenylphosphinoyl)propan-2-ol (31614-38-7) + 1-diphenylphosphanylpropan-2-ol (2652-63-3)

Guidance literature:

diphenylphosphane; With n-butyllithium; choline chloride; glycerol; In hexane; at 20 ℃; for 0.000833333h;

methyloxirane; In hexane; at 20 ℃; for 0.000833333h; chemoselective reaction;

DOI:10.1002/cssc.202001449

Reference yield:

chloro-diphenylphosphine (1079-66-9,74391-44-9) → 1-diphenylphosphanylpropan-2-ol (2652-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: LiAlH₄

With lithium aluminium tetrahydride; In diethyl ether;

upstream raw materials:

potassium diphenylphosphine

methyloxirane

1-(diphenylphosphino)propan-2-one

diphenylphosphane

Downstream raw materials:

trans-{PdCl₂(Ph₂PCH₂CHOHMe)2

(S)-(+)-(2-hydroxy-1-propyl)-diphenylphosphane

Acetic acid (R)-2-diphenylphosphanyl-1-methyl-ethyl ester

Methyl-<2-hydroxy-propyl>-diphenyl-phosphoniumjodid