1-(4-Methoxyphenyl)-3,3-diphenylpropan-1-one

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)-3,3-diphenylpropan-1-one
• CAS No.: 2657-24-1
• Molecular Formula: C22H20O2
• Molecular Weight: 316.4
• DSSTox Substance ID: DTXSID60493797
• Nikkaji Number: J1.659.824K
• Wikidata: Q82340746
• Mol file: 2657-24-1.mol

Synonyms:1-(4-Methoxyphenyl)-3,3-diphenylpropan-1-one;2657-24-1;1-(4-methoxyphenyl)-3,3-diphenyl-1-propanone;SCHEMBL2397228;DTXSID60493797

Chemical Property of 1-(4-Methoxyphenyl)-3,3-diphenylpropan-1-one

Chemical Property:

• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 316.146329876
• Heavy Atom Count: 24
• Complexity: 353

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)CC(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-(4-Methoxyphenyl)-3,3-diphenylpropan-1-one

There total 20 articles about 1-(4-Methoxyphenyl)-3,3-diphenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,1-Diphenylmethanol (91-01-0) + 3-(4-methoxy-phenyl)-3-oxo-propionic acid (13422-77-0) → 1-(4-methoxyphenyl)-3,3-diphenylpropan-1-one (2657-24-1)

Guidance literature:

1,1-Diphenylmethanol; With pentafluorophenylboronic acid; oxalic acid; In nitromethane; at 20 ℃; for 0.5h; Inert atmosphere; Glovebox;

3-(4-methoxy-phenyl)-3-oxo-propionic acid; In nitromethane; at 50 ℃; for 24h; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.1c04050

Reference yield: 93.0%

4'-methoxychalcone (959-23-9) + phenylboronic acid (98-80-6) → 1-(4-methoxyphenyl)-3,3-diphenylpropan-1-one (2657-24-1)

Guidance literature:

With nickel(II) nitrate hexahydrate; potassium hydroxide; In 1,4-dioxane; at 110 ℃; for 0.0833333h; Microwave irradiation; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201400761

Reference yield: 93.0%

(2Z)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one (30925-53-2) + phenylcerium dichloride (99354-16-2) → 1-(4-methoxyphenyl)-3,3-diphenylpropan-1-one (2657-24-1) + (Z)-1-(4-Methoxy-phenyl)-1,3-diphenyl-prop-2-en-1-ol

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 ℃; for 1.5h;

DOI:10.1016/0022-328X(85)87395-2

upstream raw materials:

4'-methoxychalcone

trans-4'-methoxychalcone

phenylcerium dichloride

(2Z)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one

Downstream raw materials:

3-(4-methoxyphenyl)-5,5-diphenyl-4,5-dihydroisoxazole

1-(4-methoxyphenyl)-3,3-diphenylpropan-1-one oxime

(3-(4-methoxyphenyl)-5,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)(phenyl)methanone

N'-(1-(4-methoxyphenyl)-3,3-diphenylpropylidene)benzohydrazide