4-Amino-2-methylbutan-2-ol

Base Information

• Chemical Name: 4-Amino-2-methylbutan-2-ol
• CAS No.: 26734-08-7
• Molecular Formula: C5H13NO
• Molecular Weight: 103.164
• Hs Code.: 2922199090
• European Community (EC) Number: 803-529-2
• DSSTox Substance ID: DTXSID70576303
• Wikidata: Q82465910
• Mol file: 26734-08-7.mol

Synonyms:4-amino-2-methylbutan-2-ol;26734-08-7;4-amino-2-methyl-2-butanol;4-Amino-2-methyl butane-2-ol;MFCD00129174;2-Butanol, 4-amino-2-methyl-;SCHEMBL103241;DTXSID70576303;PUSZHIWAFZLOMD-UHFFFAOYSA-N;AMY42489;AKOS008901420;4-AMINO-2-METHYL-BUTAN-2-OL;4-Amino-2-methylbutan-2-ol, AldrichCPR;BS-12759;SY023625;CS-0043489;A51232;EN300-152930;A903252

Chemical Property of 4-Amino-2-methylbutan-2-ol

Chemical Property:

• Melting Point: 216-218°C
• Boiling Point: 71.5 °C(Press: 10 Torr)
• PKA: 15.08±0.29(Predicted)
• PSA: 46.25000
• Density: 0.918±0.06 g/cm3(Predicted)
• LogP: 0.80640
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 103.099714038
• Heavy Atom Count: 7
• Complexity: 52

Purity/Quality:

97% ^*data from raw suppliers

4-?Amino-?2-?methyl-?2-?butanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CCN)O
• Uses: 4-?Amino-?2-?methyl-?2-?butanol is a reagent used in pharmaceutical synthesis such as tyrosine kinase 3 (FLT3) inhibitors based on 5-aryl-2-aminopyridines.

Technology Process of 4-Amino-2-methylbutan-2-ol

There total 10 articles about 4-Amino-2-methylbutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

3-hydroxy-3-methylbutyronitrile (13635-04-6) → 4-amino-2-methyl-2-butanol (26734-08-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 5h;

DOI:10.1002/anie.200700633

Reference yield: 75.88%

4-azido-2-methylbutan-2-ol (876732-44-4) → 4-amino-2-methyl-2-butanol (26734-08-7)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 80 ℃; for 20h;

Reference yield:

1-amino-3-methylbutane (107-85-7) → 4-amino-2-methyl-2-butanol (26734-08-7)

Guidance literature:

With dipotassium peroxodisulfate; sulfuric acid; In water; at 80 ℃; for 4h; Reagent/catalyst; Solvent; Sealed tube;

DOI:10.1021/acs.orglett.6b03731

upstream raw materials:

3,3-dimethylallylamine

3-hydroxy-3-methylbutyronitrile

2,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine

sulfuric acid

Downstream raw materials:

2-methyl-4-[(2-nitrophenyl)amino]-2-butanol

4-{4-[2-(2,4-difluorophenyl)-8-methylimidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-2-methyl-butan-2-ol

1-{4-[8-cyclopropylmethyl-2-(2,4-difluorophenyl)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-2-methylpropan-2-ol

1-{4-[2-(2,4-Difluorophenyl)-8-ethylimidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-2-methylpropan-2-ol