1-Isobutylpyrrolidin-2-one

Base Information

• Chemical Name: 1-Isobutylpyrrolidin-2-one
• CAS No.: 2687-92-5
• Molecular Formula: C8H15NO
• Molecular Weight: 141.213
• DSSTox Substance ID: DTXSID90396207
• Nikkaji Number: J973.434A
• Wikidata: Q82196792
• Mol file: 2687-92-5.mol

Synonyms:1-(2-methylpropyl)pyrrolidin-2-one;1-Isobutylpyrrolidin-2-one;2687-92-5;2-Pyrrolidinone, 1-(2-methylpropyl)-;N-i-butyl-2-pyrrolidone;1-Isobutyl-2-pyrrolidone;1-isobutyl-2-pyrrolidinone;SCHEMBL1303006;DTXSID90396207;IVUYGANTXQVDDG-UHFFFAOYSA-N;BDBM358090;US10214537, Example 159;AKOS015958609;1-(2-methyl-propyl)-pyrrolidin-2-one;1-(3-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H- pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)benzyl) pyrrolidin-2-one

Chemical Property of 1-Isobutylpyrrolidin-2-one

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 141.115364102
• Heavy Atom Count: 10
• Complexity: 131

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CN1CCCC1=O

Technology Process of 1-Isobutylpyrrolidin-2-one

There total 2 articles about 1-Isobutylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-isobutylpyroglutamic acid → 2-pyrrolidinon (616-45-5) + 1-isobutyl-pyrrolidin-2-one (2687-92-5) + propionic acid (802294-64-0,79-09-4)

Guidance literature:

With 4.8 wt% Pd/Al2O3 (acidic); In water; at 250 ℃; for 6h; under 4500.45 Torr; Inert atmosphere;

DOI:10.1039/c7gc01829k

Reference yield:

N-isobutylpyroglutamic acid → 1-isobutyl-pyrrolidin-2-one (2687-92-5) + propionic acid (802294-64-0,79-09-4)

Guidance literature:

With 4.8 wt% Pd/Al2O3 (acidic); ammonia; In water; at 250 ℃; for 6h; under 4500.45 Torr; Inert atmosphere;

DOI:10.1039/c7gc01829k

Reference yield:

1-isobutyl-pyrrolidin-2-one (2687-92-5) → 7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride (597583-16-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: MsOH; H₂O / 24 h / Heating

1.2: dimethylsulfoxide; H₂O / 9 h / Heating

2.1: K₂CO₃ / dimethylformamide / 1 h / 20 °C

3.1: dimethyl carbonate; NaOMe / methanol / 1 h / 60 °C

4.1: aq. NaOH / tetrahydrofuran; methanol / 1.5 h / 50 °C

5.1: Mg / tetrahydrofuran / 1 h / Heating

5.2: trimethylborate / tetrahydrofuran / 1 h / -10 °C

5.3: 86 percent / PPh₃; Pd(OAc)2; K₃PO₄ / tetrahydrofuran; H₂O / 2 h / Heating

6.1: oxalyl chloride; DMF / tetrahydrofuran / 1 h / 0 - 5 °C

With sodium hydroxide; oxalyl dichloride; methanesulfonic acid; water; sodium methylate; potassium carbonate; magnesium; N,N-dimethyl-formamide; carbonic acid dimethyl ester; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 5.3: Suzuki-Miyaura reaction;

DOI:10.1016/j.tet.2005.03.036

Downstream raw materials:

4-[(4-bromo-2-formyl-phenyl)-isobutyl-amino]-butyric acid

7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride

7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid