Technology Process of 2,5-Cyclohexadien-1-one,2-acetyl-3,5-dihydroxy-4,4-dimethyl-6-[[2,4,6-trihydroxy-3-(1-oxobutyl)phenyl]methyl]-
There total 4 articles about 2,5-Cyclohexadien-1-one,2-acetyl-3,5-dihydroxy-4,4-dimethyl-6-[[2,4,6-trihydroxy-3-(1-oxobutyl)phenyl]methyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline / dichloromethane / 20 °C
2: boron tribromide / dichloromethane / -78 - 20 °C
With
diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; boron tribromide; L-proline;
In
dichloromethane;
DOI:10.1016/j.bmc.2019.07.013
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: boron trifluoride diacetate / Heating
2.1: (-)-menthol; sodium methylate / 2 h / 0 °C
2.2: 96 h / 20 °C / Darkness
3.1: sulfuric acid / 80 °C
4.1: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline / dichloromethane / 20 °C
5.1: boron tribromide / dichloromethane / -78 - 20 °C
With
(-)-menthol; sulfuric acid; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; sodium methylate; boron trifluoride diacetate; boron tribromide; L-proline;
In
dichloromethane;
DOI:10.1016/j.bmc.2019.07.013