Phosphinic acid, (4-methylphenyl)phenyl-, ethyl ester

Base Information

• Chemical Name: Phosphinic acid, (4-methylphenyl)phenyl-, ethyl ester
• CAS No.: 26926-25-0
• Molecular Formula: C15H17O2P
• Molecular Weight: 260.273
• DSSTox Substance ID: DTXSID10468319
• Nikkaji Number: J3.061.121G
• Mol file: 26926-25-0.mol

Synonyms:Phosphinic acid, (4-methylphenyl)phenyl-, ethyl ester;26926-25-0;DTXSID10468319

Chemical Property of Phosphinic acid, (4-methylphenyl)phenyl-, ethyl ester

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 260.09661678
• Heavy Atom Count: 18
• Complexity: 289

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOP(=O)(C1=CC=CC=C1)C2=CC=C(C=C2)C

Technology Process of Phosphinic acid, (4-methylphenyl)phenyl-, ethyl ester

There total 10 articles about Phosphinic acid, (4-methylphenyl)phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-tolyl iodide (624-31-7) + ethyl Phenylphosphinate (172487-18-2,2511-09-3) → ethyl (4-methylphenyl)phenylphosphinate (26926-25-0)

Guidance literature:

With copper(l) iodide; caesium carbonate; rac-Pro-OH; In toluene; at 110 ℃; for 24h;

DOI:10.1021/jo060492j

Reference yield: 83.0%

4-methylphenyl tosylate (3899-96-5) + ethyl Phenylphosphinate (172487-18-2,2511-09-3) → ethyl (4-methylphenyl)phenylphosphinate (26926-25-0)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; N-ethyl-N,N-diisopropylamine; zinc; In N,N-dimethyl-formamide; at 100 ℃; for 36h; Inert atmosphere;

DOI:10.1039/c2ob25225b

Reference yield: 73.0%

ethyl Phenylphosphinate (172487-18-2,2511-09-3) + 4-tolyl perfluorobutanesulfonate (93131-73-8) → ethyl (4-methylphenyl)phenylphosphinate (26926-25-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 4h; Inert atmosphere; Microwave irradiation; Heating; Sealed tube;

DOI:10.1021/acs.joc.1c02172

upstream raw materials:

para-bromotoluene

diethyl phenylphosphonate

diethyl phenylphosphonite

4-methylbenzenediazonium tetrafluoroborate

Downstream raw materials:

C₁₄H₁₆NO₄PS

N-hydroxylamine

p-Tolyl-phenyl-phosphinigsaeurechlorid

P-phenyl-P-methoxy-N-(p-tolyl) phosphonamide