4-Chloro-N-(2-chlorophenyl)butyramide

Base Information

• Chemical Name: 4-Chloro-N-(2-chlorophenyl)butyramide
• CAS No.: 26974-78-7
• Molecular Formula: C10H11Cl2NO
• Molecular Weight: 232.109
• DSSTox Substance ID: DTXSID401288609
• Mol file: 26974-78-7.mol

Synonyms:4-Chloro-N-(2-chlorophenyl)butyramide;26974-78-7;4-chloro-N-(2-chlorophenyl)butanamide;Enamine_000303;DTXSID401288609;HMS1394N17;MFCD01336096;AKOS000149394;Z56764348

Chemical Property of 4-Chloro-N-(2-chlorophenyl)butyramide

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 231.0217694
• Heavy Atom Count: 14
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NC(=O)CCCCl)Cl

Technology Process of 4-Chloro-N-(2-chlorophenyl)butyramide

There total 2 articles about 4-Chloro-N-(2-chlorophenyl)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

o-chloroaniline (95-51-2) + 4-Chlorobutanoyl chloride (4635-59-0) → 4-Chloro-N-(2-chloro-phenyl)-butyramide (26974-78-7)

Guidance literature:

With acetic acid; at 0 - 20 ℃; for 1.5h;

DOI:10.1016/S0014-827X(01)01197-1

Reference yield:

→ 4-Chloro-N-(2-chloro-phenyl)-butyramide (26974-78-7)

Guidance literature:

Amin durch Acyl.;

Reference yield: 92.0%

4-Chloro-N-(2-chloro-phenyl)-butyramide (26974-78-7) → 4-azido-N-(2-chlorophenyl)butyramide (1286232-03-8)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.tetlet.2011.01.088

upstream raw materials:

o-chloroaniline

4-Chlorobutanoyl chloride

Downstream raw materials:

4-azido-N-(2-chlorophenyl)butyramide

N-(2-chlorophenyl)tetramethylenediamine