1,4-bis(chloromethyl)piperazine-2,5-dione

Base Information

• Chemical Name: 1,4-bis(chloromethyl)piperazine-2,5-dione
• CAS No.: 64028-43-9
• Molecular Formula: C₆H₈Cl₂N₂O₂
• Molecular Weight: 211.048
• Mol file: 64028-43-9.mol

Synonyms:1,4-Bis(chloromethyl)-2,5-diketopiperazine;1,4-Bis(chloromethyl)-2,5-piperazinedione; NSC 208909

Chemical Property of 1,4-bis(chloromethyl)piperazine-2,5-dione

Chemical Property:

• Vapor Pressure: 8.4E-08mmHg at 25°C
• Boiling Point: 436°C at 760 mmHg
• Flash Point: 217.5°C
• Density: 1.44g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-bis(chloromethyl)piperazine-2,5-dione

There total 2 articles about 1,4-bis(chloromethyl)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

1,4-di(hydroxymethyl)-2,5-diketopiperazine (7383-56-4) → 1,4-di(chloromethyl)-2,5-diketopiperazine (64028-43-9)

Guidance literature:

With thionyl chloride; In chloroform; for 3.5h; Heating;

DOI:10.1007/BF00957969

Reference yield:

→ 1,4-di(chloromethyl)-2,5-diketopiperazine (64028-43-9)

Guidance literature:

With tetrachloromethane; phosphorus pentachloride; acetyl chloride;

Reference yield:

1,4-di(chloromethyl)-2,5-diketopiperazine (64028-43-9) + ethanol (64-17-5) → 1,4-bis-ethoxymethyl-piperazine-2,5-dione

Guidance literature:

upstream raw materials:

1,4-di(hydroxymethyl)-2,5-diketopiperazine

Downstream raw materials:

N,N'-dibenzylpiperazine-2,5-dione