7,7-DIMETHYL-4-PHENYL-4,6,7,8-TETRAHYDRO-2H-CHROMENE-2,5(3H)-DIONE

Base Information

• Chemical Name: 7,7-DIMETHYL-4-PHENYL-4,6,7,8-TETRAHYDRO-2H-CHROMENE-2,5(3H)-DIONE
• CAS No.: 27044-89-9
• Molecular Formula: C17H18O3
• Molecular Weight: 270.328

Synonyms:7,7-dimethyl-4-phenyl-4,6,7,8-tetrahydro-3H-chromene-2,5-dione;4-phenyl-7,7-dimethyl-4,6,7,8-tetrahydro-2H-chromene-2,5(3H)-dione;7,7-dimethyl-4-phenyl-3,4,7,8-tetrahydro-2H-chromene-2,5(6H)-dione;

Chemical Property of 7,7-DIMETHYL-4-PHENYL-4,6,7,8-TETRAHYDRO-2H-CHROMENE-2,5(3H)-DIONE

Chemical Property:

• Boiling Point: 435.9±45.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 3.36030

Purity/Quality:

7,7-DIMETHYL-4-PHENYL-4,6,7,8-TETRAHYDRO-2H-CHROMENE-2,5(3H)-DIONE 95.00% ^*data from reagent suppliers

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Technology Process of 7,7-DIMETHYL-4-PHENYL-4,6,7,8-TETRAHYDRO-2H-CHROMENE-2,5(3H)-DIONE

There total 6 articles about 7,7-DIMETHYL-4-PHENYL-4,6,7,8-TETRAHYDRO-2H-CHROMENE-2,5(3H)-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dimedone (126-81-8) + (E)-4-bromo-1-(3-phenyl-2-propenoyl)-3,5-dimethylpyrazole (575489-76-8) → 4,6,7,8-tetrahydro-7,7-dimethyl-4-phenyl-2H-1-benzopyran-2,5(3H)-dione (27044-89-9)

Guidance literature:

With thymidine 5'-phosphate; nickel(II) perchlorate; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/S0040-4039(03)00147-3

Reference yield: 91.0%

cycl-isopropylidene malonate (2033-24-1) + benzaldehyde (100-52-7) + dimedone (126-81-8) → 4,6,7,8-tetrahydro-7,7-dimethyl-4-phenyl-2H-1-benzopyran-2,5(3H)-dione (27044-89-9)

Guidance literature:

With copper(I) iodide; In neat (no solvent); at 20 ℃; for 0.25h; Time; Green chemistry;

DOI:10.1515/znb-2015-0195

Reference yield: 80.0%

5,5-dimethyl-3-oxocyclohex-1-enyl cinnamate (24934-10-9) → 4,6,7,8-tetrahydro-7,7-dimethyl-4-phenyl-2H-1-benzopyran-2,5(3H)-dione (27044-89-9)

Guidance literature:

With potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride; In toluene; at 0 ℃;

DOI:10.1021/ja905501z

upstream raw materials:

dimedone

(E)-4-bromo-1-(3-phenyl-2-propenoyl)-3,5-dimethylpyrazole

5,5-dimethyl-3-oxocyclohex-1-enyl cinnamate

(E)-3-oxocyclohex-1-en-1-yl 3-(2-methoxyphenyl)acrylate

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