Benzenamine, 4-(4-aminophenoxy)-3-(trifluoromethyl)-

Base Information

• Chemical Name: Benzenamine, 4-(4-aminophenoxy)-3-(trifluoromethyl)-
• CAS No.: 270923-67-6
• Molecular Formula: C13H11F3N2O
• Molecular Weight: 268.238
• DSSTox Substance ID: DTXSID70463825
• Nikkaji Number: J1.309.373C
• Wikidata: Q82288879
• Mol file: 270923-67-6.mol

Synonyms:Benzenamine, 4-(4-aminophenoxy)-3-(trifluoromethyl)-;270923-67-6;4-(4-aminophenoxy)-3-(trifluoromethyl)aniline;SCHEMBL1352801;DTXSID70463825;SYLFKCCCMAKZKF-UHFFFAOYSA-N;2-trifluoromethyl-4,4'-diaminodiphenyl ether

Chemical Property of Benzenamine, 4-(4-aminophenoxy)-3-(trifluoromethyl)-

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 268.08234746
• Heavy Atom Count: 19
• Complexity: 290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)OC2=C(C=C(C=C2)N)C(F)(F)F

Technology Process of Benzenamine, 4-(4-aminophenoxy)-3-(trifluoromethyl)-

There total 5 articles about Benzenamine, 4-(4-aminophenoxy)-3-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

2-trifluoromethyl-4,4'-dinitrodiphenyl ether (21726-23-8) → 2-trifluoromethyl-4-aminophenyl 4-aminophenyl ether (270923-67-6)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; at 30 - 65 ℃; for 4h;

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 2-trifluoromethyl-4-aminophenyl 4-aminophenyl ether (270923-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / K₂CO₃ / N,N-dimethyl-acetamide / 12 h / 100 °C

2: 84 percent / hydrazine monohydrate / 10 percent Pd/C / ethanol / 2 h / Heating

With potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide;

DOI:10.1002/jccs.200200131

Reference yield:

4-chloro-3-(trifluoromethyl)nitrobenzene (777-37-7) → 2-trifluoromethyl-4-aminophenyl 4-aminophenyl ether (270923-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / K₂CO₃ / N,N-dimethyl-acetamide / 12 h / 100 °C

2: 84 percent / hydrazine monohydrate / 10 percent Pd/C / ethanol / 2 h / Heating

With potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide;

DOI:10.1002/jccs.200200131

upstream raw materials:

2-trifluoromethyl-4,4'-dinitrodiphenyl ether

4-nitro-phenol

4-chloro-3-(trifluoromethyl)nitrobenzene

1-chloro-2-(trifluoromethyl)benzene