tert-Butyl methyl(3-oxopropyl)carbamate

Base Information

Chemical Name:tert-Butyl methyl(3-oxopropyl)carbamate
CAS No.:273757-11-2
Molecular Formula:C9H17NO3
Molecular Weight:187.239
Hs Code.:2924199090
European Community (EC) Number:873-574-0
DSSTox Substance ID:DTXSID60439933
Nikkaji Number:J3.541.256E
Mol file:273757-11-2.mol

Synonyms:273757-11-2;tert-Butyl methyl(3-oxopropyl)carbamate;Tert-butyl N-methyl-N-(3-oxopropyl)carbamate;Methyl-(3-oxo-propyl)-carbamic acid tert-butyl ester;N-Boc-N-methyl-3-amino-propanaldehyde;SCHEMBL380577;DTXSID60439933;JBAKABOTZNERRZ-UHFFFAOYSA-N;Carbamic acid, methyl(3-oxopropyl)-, 1,1-dimethylethyl ester;AB8776;MFCD09751791;tert-Butylmethyl(3-oxopropyl)carbamate;SB36330;AS-44915;3-(Methyl tert-butoxycarbonylamino)propanal;FT-0764405;J3.541.256E;EN300-199178;1,1-Dimethylethyl N-methyl-(3-oxopropyl)carbamate;methyl(3-oxopropyl)carbamic acid, 1,1-dimethylethyl ester;Methyl-(3-oxopropyl)carbamic acid, 1,1-dimethylethyl ester;N-Methyl-(3-oxopropyl)carbamic acid, 1,1-dimethylethyl ester

Suppliers and Price of tert-Butyl methyl(3-oxopropyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Boc-N-methyl-3-amino-propanaldehyde
500mg
$ 330.00

Labseeker
tert-butyl2-formylethylmethylcarbamate 95
1g
$ 1100.00

J&W Pharmlab
Methyl-(3-oxo-propyl)-carbamicacidtert-butylester 96%
50mg
$ 95.00

Crysdot
tert-Butylmethyl(3-oxopropyl)carbamate 95+%
10g
$ 1079.00

Crysdot
tert-Butylmethyl(3-oxopropyl)carbamate 95+%
5g
$ 700.00

American Custom Chemicals Corporation
TERT-BUTYL 2-FORMYLETHYLMETHYLCARBAMATE 95.00%
5MG
$ 495.04

Acrotein
N-Boc-N-methyl-3-amino-propanaldehyde 97%
0.25g
$ 146.67

Total 10 raw suppliers

Chemical Property of tert-Butyl methyl(3-oxopropyl)carbamate

Chemical Property:

Boiling Point:250.5±19.0 °C(Predicted)
PKA:-1.43±0.70(Predicted)
PSA：46.61000
Density:1.011±0.06 g/cm3(Predicted)
LogP:1.44230
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
XLogP3:0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:187.12084340
Heavy Atom Count:13
Complexity:184

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-N-methyl-3-amino-propanaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N(C)CCC=O

Technology Process of tert-Butyl methyl(3-oxopropyl)carbamate

There total 1 articles about tert-Butyl methyl(3-oxopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 273757-11-2
tert-butyl methyl(3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 0.17 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 10 °C

2.2: 10 - 20 °C

3.1: water; acetic acid / tetrahydrofuran / 0 - 20 °C

4.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate / dichloromethane; water / 0.75 h / 0 °C

With 1H-imidazole; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; sodium hydride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; dichloromethane; water;

Reference yield: 99.0%

: (R)-methyl 3-(2-((S)-3-((S)-3-amino-4-(4-(methylsulfonyl)phenyl)butanamido)-2-oxo-2,3,4,5-tetrahydro-1Hbenzo[b]azepin-1-yl)acetamido)-4-(3,4-dichlorophenyl)butanoate

: 273757-11-2
tert-butyl methyl(3-oxopropyl)carbamate

: C₄₃H₅₅Cl₂N₅O₉S

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 23 ℃; for 0.5h;
DOI:10.1021/acsmedchemlett.6b00464

Reference yield: 74.0%

: (R)-methyl 3-(2-((S)-3-((S)-3-amino-4-(4-chlorophenyl)butanamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetamido)-4-(3-bromo-4-chlorophenyl)butanoate

: 273757-11-2
tert-butyl methyl(3-oxopropyl)carbamate

: (R)-methyl 4-(3-bromo-4-chlorophenyl)-3-(2-((S)-3-((S)-3-((3-((tertbutoxycarbonyl)(methyl)amino)propyl)amino)-4-(4-chlorophenyl)butanamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetamido)butanoate

Guidance literature:: (R)-methyl 3-(2-((S)-3-((S)-3-amino-4-(4-chlorophenyl)butanamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetamido)-4-(3-bromo-4-chlorophenyl)butanoate; tert-butyl methyl(3-oxopropyl)carbamate; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1021/acsmedchemlett.6b00464