N,N-dibenzyl-3-phenylpropan-1-amine

Base Information

• Chemical Name: N,N-dibenzyl-3-phenylpropan-1-amine
• CAS No.: 27376-59-6
• Molecular Formula: C23H25N
• Molecular Weight: 315.458
• DSSTox Substance ID: DTXSID10397615
• Nikkaji Number: J2.547.772C
• Mol file: 27376-59-6.mol

Synonyms:N,N-dibenzyl-3-phenylpropan-1-amine;3-Phenylpropyldibenzylamine;Oprea1_316000;27376-59-6;SCHEMBL8828024;DTXSID10397615;AB00041536-01

Chemical Property of N,N-dibenzyl-3-phenylpropan-1-amine

Chemical Property:

• XLogP3: 5.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 8
• Exact Mass: 315.198699802
• Heavy Atom Count: 24
• Complexity: 288

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCCN(CC2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of N,N-dibenzyl-3-phenylpropan-1-amine

There total 14 articles about N,N-dibenzyl-3-phenylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(N,N)-dibenzyl-3-phenylpropanamide (180747-56-2) → N,N-dibenzyl-N-(3-phenylpropyl)amine (27376-59-6)

Guidance literature:

(N,N)-dibenzyl-3-phenylpropanamide; With 1,1,3,3-Tetramethyldisiloxane; In 1,1,2,2-tetrachloroethane; at 100 ℃; for 15h; Inert atmosphere; Schlenk technique;

With sodium hydroxide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.202001061

Reference yield: 78.0%

1-Bromo-3-phenylpropane (637-59-2) + dibenzylamine (103-49-1) → N,N-dibenzyl-N-(3-phenylpropyl)amine (27376-59-6)

Guidance literature:

With diethylene glycol dimethyl ether; potassium carbonate; at 140 ℃;

DOI:10.1021/jo00001a090

Reference yield: 67.0%

hydrocinnamanilide (3271-81-6) + dibenzylamine (103-49-1) → N,N-dibenzyl-N-(3-phenylpropyl)amine (27376-59-6)

Guidance literature:

With indium(III) bromide; phenylsilane; In toluene; at 100 ℃; for 20h; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201601629

upstream raw materials:

1-Bromo-3-phenylpropane

dibenzylamine

N,N-dibenzyl-N-(3-phenylprop-1-enyl)amine

3-phenyl-propionaldehyde

Downstream raw materials:

3-phenylpropylamine hydrochloride