(N,N)-dibenzyl-3-phenylpropanamide

Base Information

• Chemical Name: (N,N)-dibenzyl-3-phenylpropanamide
• CAS No.: 180747-56-2
• Molecular Formula: C₂₃H₂₃NO
• Molecular Weight: 329.442
• Mol file: 180747-56-2.mol

Synonyms:(N,N)-dibenzyl-3-phenylpropanamide

Chemical Property of (N,N)-dibenzyl-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (N,N)-dibenzyl-3-phenylpropanamide

There total 17 articles about (N,N)-dibenzyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

hydrocinnamic acid chloride (645-45-4) + dibenzylamine (103-49-1) → (N,N)-dibenzyl-3-phenylpropanamide (180747-56-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1002/anie.201701538

Reference yield: 91.0%

3-Phenylpropionic acid (501-52-0) + dibenzylamine (103-49-1) → (N,N)-dibenzyl-3-phenylpropanamide (180747-56-2)

Guidance literature:

With 4-methyl-morpholine; 4-(5-allyl-6-isopropoxy-4-oxo-4,5-dihydro-1,3,5-triazine-2-yl)-4-methylmorpholine-4-ium chloride; In methanol; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.9b01261

Reference yield: 88.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + carbon monoxide (201230-82-2) + dibenzylamine (103-49-1) → N,N-dibenzyl-2-phenylpropanamide + (N,N)-dibenzyl-3-phenylpropanamide (180747-56-2)

Guidance literature:

With palladium(II) trifluoroacetate; 1,5-bis-(diphenylphosphino)pentane; glycine ethyl ester hydrochloride; In water; at 120 ℃; for 21h; under 7600.51 Torr; Reagent/catalyst; regioselective reaction; Autoclave;

DOI:10.1002/anie.201502405

upstream raw materials:

N,N-dibenzyl-3-hydroxy-3-phenylpropanamide

(E)-N,N-dibenzyl-3-phenylprop-2-enamide

styrene

dibenzylcarbamyl chloride

Downstream raw materials:

N,N-dibenzyl-N-(3-phenylpropyl)amine

1-phenylpentan-3-one

3-Phenyl-1-propanol

dibenzylamine