3-aMino-2-naphthaMide

Base Information

• Chemical Name: 3-aMino-2-naphthaMide
• CAS No.: 27533-32-0
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.213
• Mol file: 27533-32-0.mol

Synonyms:3-amino-[2]naphthoic acid amide;2-Naphthalenecarboxamide, 3-amino-;3-Amino-naphthamid-(2);3-amino-2-naphthalenecarboxamide;2-Aminonaphthalin-3-carboxamid;2-Amino-3-naphthamid;3-Amino-[2]naphthoesaeure-amid;3-Amino-naphthalene-2-carboxylic acid amide;

Chemical Property of 3-aMino-2-naphthaMide

Chemical Property:

• Melting Point: 234-236 °C
• Boiling Point: 410.4±18.0 °C(Predicted)
• PKA: 16.55±0.30(Predicted)
• PSA: 69.11000
• Density: 1.288±0.06 g/cm3(Predicted)
• LogP: 2.80240
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Amino-2-naphthamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-aMino-2-naphthaMide

There total 4 articles about 3-aMino-2-naphthaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-Amino-3-naphthoic acid (5959-52-4) → 2-aminonaphthalene-3-carboxamide (27533-32-0)

Guidance literature:

2-Amino-3-naphthoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

With ammonia; In tetrahydrofuran; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.7b00643

Reference yield:

2H-naphth<2,3-d><3,1>oxazine-2,4(1H)-dione (29753-32-0) → 2-aminonaphthalene-3-carboxamide (27533-32-0)

Guidance literature:

With ammonia; water; In tetrahydrofuran; toluene; at 0 ℃; for 1h;

Reference yield:

2H-Naphtho<2,3-e>-1,3-oxazin-2,4(3H)-dion (53653-44-4) → 2-aminonaphthalene-3-carboxamide (27533-32-0)

Guidance literature:

With ethanol; ammonia;

upstream raw materials:

2H-Naphtho<2,3-e>-1,3-oxazin-2,4(3H)-dion

2H-naphth<2,3-d><3,1>oxazine-2,4(1H)-dione

2-Amino-3-naphthoic acid

Downstream raw materials:

2-phenylbenzo[g]quinazolin-4(3H)-one

Refernces

• 1、 Tomassi, Stefano,Pfahler, Julian,Mautone, Nicola,Rovere, Annarita,Esposito, Chiara,Passeri, Daniela,Pellicciari, Roberto,Novellino, Ettore,Pannek, Martin,Steegborn, Clemens,Paiardini, Alessandro,Mai, Antonello,Rotili, Dante. "From PARP1 to TNKS2 inhibition: A structure-based approach". supporting information. p. 862 - 868. Retrieved 2020/06/30.
• 2、 -. "2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER". Page/Page column 69. . Retrieved 2009/04/25.