29753-32-0

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 5959-52-4 2-Amino-3-naphthoic acid 
• 75-44-5 phosgene 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 144221-35-2 2-(4-Methoxy-phenyl)-3-phenyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-32-9 2,3-dihydro-3-(4-methylphenyl)-2-phenylbenzoquinazolin-4(1H)-one 
• 144221-34-1 3-Phenyl-2-p-tolyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-33-0 3-(4-Bromo-phenyl)-2-phenyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-36-3 2-(4-Chloro-phenyl)-3-phenyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-37-4 2-(4-Nitro-phenyl)-3-phenyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-38-5 2,3-Bis-(4-chloro-phenyl)-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-39-6 3-(4-Bromo-phenyl)-2-p-tolyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-40-9 3-(4-Bromo-phenyl)-2-(4-nitro-phenyl)-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-52-3 2-Isobutyl-2-methyl-3-phenyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-53-4 2-Methyl-2,3-diphenyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 144221-51-2 2-Ethyl-2-methyl-3-phenyl-2,3-dihydro-1H-benzo[g]quinazolin-4-one 
• 27533-32-0 2-aminonaphthalene-3-carboxamide 
• 21597-54-6 Methyl 3-amino-2-naphthoate 

Relevant academic research and scientific papers

Fluorescent 1-hydroxy-10-alkylacridin-9(10H)-one BF2-chelates: Large Stokes shift and long emission decay times

New 1-hydroxy-10-alkylacridin-9(10H)-one BF2-chelates absorb in the blue-green part of the electromagnetic spectrum and emit fluorescence with moderate quantum yields of 8–45% in toluene. The dyes show large Stokes shifts about 4300 cm?1, decay times between 5 ns and 15 ns in toluene and high photostabilities. Introduction of a fluorine atom into the acridone cycle results in an increase of the fluorescence quantum yield and decay time whereas immobilization in a rigid polymer matrix (polystyrene) further extends the lifetime up to 18 ns. Large Stokes shifts and long emission decay time make this dye class an interesting platform for time-resolved imaging and sensing applications.

Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using p Ka-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam

An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam 3, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.

Synthesis of benzo-annulated tryptanthrins and their biological properties

A series of benzo-annulated derivatives of tryptanthrin were prepared and their optical and redox properties were studied. Tryptanthrin and its benzo-annulated derivatives showed selective inhibitory activity on topo I with an increase of activity on topo II by benzo-annulation on quinazolin-4(3H)-one moiety. Although the benzo-annulation on quinazolin-4(3H)-one ring did not affect significantly on the inhibitory activities against topo I and II, the benzoannulation on indolin-3-one ring affected the inhibitory activity very much especially by linear annulation. Cytotoxicities were not significantly changed upon benzoannulation, which were not directly related either to the inhibitory activities against topo I and II or to the reduction potentials.

2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D] PYRIMIDIN-4-YL) AMINO] BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER

Novel pyrrolopyrimidines as shown in formula (I) and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.

One-pot synthesis of 2,3-dihydro-2,3-disubstituted benzo[g]quinazolin-4(1H)-ones

Condensation of 2H-naphth[2,3-d][3,1]oxazin-2,4 (1H)-dione (1) with schiff bases (2) in acetic acid resulted in the formation of 2,3-dihydro-2,3-diarylbenzo[g]quinazolin-4 (1H)-ones (3). Reaction of 1 with ketoanils generated in situ results in 2,3-dihydr