Ethyl 4-hydroxy-1H-indole-2-carboxylate

Base Information

Chemical Name:Ethyl 4-hydroxy-1H-indole-2-carboxylate
CAS No.:27737-56-0
Molecular Formula:C11H11NO3
Molecular Weight:205.213
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10533935
Wikidata:Q82407502
Mol file:27737-56-0.mol

Synonyms:Ethyl 4-hydroxy-1H-indole-2-carboxylate;27737-56-0;ethyl 4-hydroxyindole-2-carboxylate;4-hydroxy-1H-indole-2-carboxylic acid ethyl ester;SCHEMBL913891;2-ethoxycarbonyl-4-hydroxyindole;DTXSID10533935;4-hydroxy 2-ethoxycarbonyl indole;ZJZAFABAVBYFQO-UHFFFAOYSA-N;CBA73756;MFCD18711665;AKOS022183508;Ethyl4-hydroxy-1H-indole-2-carboxylate;AS-41888;CS-0103602;J-521014

Suppliers and Price of Ethyl 4-hydroxy-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl4-Hydroxy-1H-indole-2-carboxylate
100mg
$ 330.00

Matrix Scientific
Ethyl 4-hydroxy-1H-indole-2-carboxylate
1g
$ 676.00

Crysdot
Ethyl4-hydroxy-1H-indole-2-carboxylate 95+%
1g
$ 451.00

Chemenu
Ethyl4-hydroxy-1H-indole-2-carboxylate 95%
1g
$ 425.00

Alichem
Ethyl4-hydroxy-1H-indole-2-carboxylate
5g
$ 2190.90

Alichem
Ethyl4-hydroxy-1H-indole-2-carboxylate
25g
$ 5113.44

AccelPharmtech
4-hydroxy-1H-Indole-2-carboxylicacidethylester 97.00%
25G
$ 6000.00

AccelPharmtech
4-hydroxy-1H-Indole-2-carboxylicacidethylester 97.00%
5G
$ 3230.00

AccelPharmtech
4-hydroxy-1H-Indole-2-carboxylicacidethylester 97.00%
1G
$ 1890.00

Total 6 raw suppliers

Chemical Property of Ethyl 4-hydroxy-1H-indole-2-carboxylate

Chemical Property:

Boiling Point:410.4±25.0 °C(Predicted)
PKA:9.08±0.40(Predicted)
PSA：62.32000
Density:1.326±0.06 g/cm3(Predicted)
LogP:2.05020
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:205.07389321
Heavy Atom Count:15
Complexity:244

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl4-Hydroxy-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CC2=C(N1)C=CC=C2O

Technology Process of Ethyl 4-hydroxy-1H-indole-2-carboxylate

There total 5 articles about Ethyl 4-hydroxy-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 27737-55-9
4-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

: 27737-56-0
4-hydroxy-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; for 24h;

Reference yield:

: 90-02-8
salicylaldehyde

: 27737-56-0
4-hydroxy-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2: sodium; ethyl trifluoroacetate,; ethanol / 2.08 h / -10 - 20 °C / Inert atmosphere

3: 160 °C

4: palladium 10% on activated carbon; hydrogen / methanol

With ethanol; ethyl trifluoroacetate,; palladium 10% on activated carbon; hydrogen; sodium; sodium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.10.029

Reference yield:

: 5896-17-3
2-(phenylmethoxy)benzaldehyde

: 27737-56-0
4-hydroxy-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium; ethyl trifluoroacetate,; ethanol / 2.08 h / -10 - 20 °C / Inert atmosphere

2: 160 °C

3: palladium 10% on activated carbon; hydrogen / methanol

With ethanol; ethyl trifluoroacetate,; palladium 10% on activated carbon; hydrogen; sodium; In methanol;
DOI:10.1016/j.bmc.2018.10.029