Ethyl (2Z)-2-azido-3-[2-(phenylmethoxy)phenyl]-2-propenoate

Base Information

Chemical Name:Ethyl (2Z)-2-azido-3-[2-(phenylmethoxy)phenyl]-2-propenoate
CAS No.:95264-30-5
Molecular Formula:C18H17N3O3
Molecular Weight:323.351
Hs Code.:
European Community (EC) Number:619-120-5
DSSTox Substance ID:DTXSID201190494

Synonyms:DTXSID201190494;Ethyl (2Z)-2-azido-3-[2-(phenylmethoxy)phenyl]-2-propenoate;95264-30-5

Suppliers and Price of Ethyl (2Z)-2-azido-3-[2-(phenylmethoxy)phenyl]-2-propenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Ethyl (2Z)-2-azido-3-[2-(phenylmethoxy)phenyl]-2-propenoate

Chemical Property:

XLogP3:5.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:323.12699141
Heavy Atom Count:24
Complexity:480

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(=CC1=CC=CC=C1OCC2=CC=CC=C2)N=[N+]=[N-]
Isomeric SMILES:CCOC(=O)/C(=C/C1=CC=CC=C1OCC2=CC=CC=C2)/N=[N+]=[N-]

Technology Process of Ethyl (2Z)-2-azido-3-[2-(phenylmethoxy)phenyl]-2-propenoate

There total 3 articles about Ethyl (2Z)-2-azido-3-[2-(phenylmethoxy)phenyl]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 637-81-0
ethyl-2-azidoacetate

: 5896-17-3
2-(phenylmethoxy)benzaldehyde

: 95264-30-5
(Z)-ethyl 2-azido-3-(2-(benzyloxy)phenyl)acrylate

Guidance literature:: With ethanol; ethyl trifluoroacetate,; sodium; at -10 - 20 ℃; for 2.08333h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.10.029

Reference yield:

: 90-02-8
salicylaldehyde

: 95264-30-5
(Z)-ethyl 2-azido-3-(2-(benzyloxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2: sodium; ethyl trifluoroacetate,; ethanol / 2.08 h / -10 - 20 °C / Inert atmosphere

With ethanol; ethyl trifluoroacetate,; sodium; sodium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.10.029

Reference yield:

: 100-39-0
benzyl bromide

: 95264-30-5
(Z)-ethyl 2-azido-3-(2-(benzyloxy)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2: sodium; ethyl trifluoroacetate,; ethanol / 2.08 h / -10 - 20 °C / Inert atmosphere

With ethanol; ethyl trifluoroacetate,; sodium; sodium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2018.10.029