3-Methyl-4-[3-(pyridin-3-ylmethylamino)propoxy]-1-benzofuran-2-carboxylic acid ethyl ester

Base Information

Chemical Name:3-Methyl-4-[3-(pyridin-3-ylmethylamino)propoxy]-1-benzofuran-2-carboxylic acid ethyl ester
CAS No.:279230-20-5
Molecular Formula:C₂₁H₂₄N₂O₄
Molecular Weight:368.433
Hs Code.:
Mol file:279230-20-5.mol

Synonyms:3-methyl-4-{3-[(pyridin-3-ylmethyl)-amino]-propoxy}-benzofuran-2-carboxylic acid ethyl ester;RO-09-4609;

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Chemical Property of 3-Methyl-4-[3-(pyridin-3-ylmethylamino)propoxy]-1-benzofuran-2-carboxylic acid ethyl ester

Chemical Property:

Boiling Point:531.7±50.0 °C(Predicted)
PKA:8.51±0.40(Predicted)
PSA：73.59000
Density:1.176±0.06 g/cm3(Predicted)
LogP:4.26250

Purity/Quality:

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Technology Process of 3-Methyl-4-[3-(pyridin-3-ylmethylamino)propoxy]-1-benzofuran-2-carboxylic acid ethyl ester

There total 7 articles about 3-Methyl-4-[3-(pyridin-3-ylmethylamino)propoxy]-1-benzofuran-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 3731-52-0
3-Aminomethylpyridine

: 279230-75-0
4-(3-bromopropoxy)-3-methylbenzofuran-2-carboxylic acid ethyl ester

: 279230-20-5
ethyl 3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)benzofuran-2-carboxylate

Guidance literature:: In ethanol; at 60 ℃; for 9h;
DOI:10.1016/S0968-0896(03)00429-2

Reference yield:

: 3781-69-9
4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

: 279230-20-5
ethyl 3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)benzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / potassium carbonate / dimethylformamide / 4 h / 20 °C

2: 77 percent / ethanol / 9 h / 60 °C

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00429-2

Reference yield:

: 699-83-2
2,6-dihydroxylacetophenone

: 279230-20-5
ethyl 3-methyl-4-(3-(pyridin-3-ylmethylamino)propoxy)benzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / acetone / 15 h / 60 °C

2: NaOEt / ethanol / 20 h / 0 °C

3: K₂CO₃ / dimethylformamide / 20 °C

4: ethanol / 70 °C

With sodium ethanolate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(01)00319-5