4'ξ-[(tert-butyl-dimethyl-silanyloxy)-methyl]-2'-cyclohexyl-3β-methoxy-(5α,16β,17β)-tetrahydro-androstano[16,17-e][1,2]oxazine-3'ξ-carbonitrile

Base Information

• Chemical Name: 4'ξ-[(tert-butyl-dimethyl-silanyloxy)-methyl]-2'-cyclohexyl-3β-methoxy-(5α,16β,17β)-tetrahydro-androstano[16,17-e][1,2]oxazine-3'ξ-carbonitrile
• CAS No.: 72166-06-4
• Molecular Formula: C₃₆H₆₂N₂O₃Si
• Molecular Weight: 598.985
• Mol file: 72166-06-4.mol

Synonyms:

Chemical Property of 4'ξ-[(tert-butyl-dimethyl-silanyloxy)-methyl]-2'-cyclohexyl-3β-methoxy-(5α,16β,17β)-tetrahydro-androstano[16,17-e][1,2]oxazine-3'ξ-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'ξ-[(tert-butyl-dimethyl-silanyloxy)-methyl]-2'-cyclohexyl-3β-methoxy-(5α,16β,17β)-tetrahydro-androstano[16,17-e][1,2]oxazine-3'ξ-carbonitrile

There total 1 articles about 4'ξ-[(tert-butyl-dimethyl-silanyloxy)-methyl]-2'-cyclohexyl-3β-methoxy-(5α,16β,17β)-tetrahydro-androstano[16,17-e][1,2]oxazine-3'ξ-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexyl-oxiranylmethylene-amine oxide (69739-33-9) + t-butyldimethylsiyl triflate (69739-34-0) + 3β-methoxy-(5α)-androst-16-ene (72166-02-0) + potassium cyanide (151-50-8) → 4'ξ-[(tert-butyl-dimethyl-silanyloxy)-methyl]-2'-cyclohexyl-3β-methoxy-(5α,16β,17β)-tetrahydro-androstano[17,16-e][1,2]oxazine-3'ξ-carbonitrile (72166-07-5) + 4'ξ-[(tert-butyl-dimethyl-silanyloxy)-methyl]-2'-cyclohexyl-3β-methoxy-(5α,16β,17β)-tetrahydro-androstano[16,17-e][1,2]oxazine-3'ξ-carbonitrile (72166-06-4)

Guidance literature:

Multistep reaction; (i) CH₂Cl₂, (ii) /BRN= 4652394/, H₂O;

DOI:10.1002/hlca.19790620524

upstream raw materials:

cyclohexyl-oxiranylmethylene-amine oxide

t-butyldimethylsiyl triflate

3β-methoxy-(5α)-androst-16-ene

potassium cyanide