Ethyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate

Base Information

Chemical Name:Ethyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
CAS No.:28125-84-0
Deprecated CAS:5497-43-8
Molecular Formula:C9H15NO2
Molecular Weight:169.22100
Hs Code.:2933399090
DSSTox Substance ID:DTXSID30182404
Nikkaji Number:J21.628C
Wikidata:Q83053080
Metabolomics Workbench ID:48160
Mol file:28125-84-0.mol

Synonyms:28125-84-0;Ethyl 1-methyl-1,2,5,6-tetrahydronicotinate;ethyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate;Homoarecoline;Arecaidine Ethyl Ester;Arecaidine-ethyl ester;ethyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;BRN 0125290;NICOTINIC ACID, 1,2,5,6-TETRAHYDRO-1-METHYL-, ETHYL ESTER;3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, ethyl ester;SCHEMBL7276350;Ethyl1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate;DTXSID30182404;CHEBI:166574;AMY36658;AKOS015850968;LS-96621;A5371;FT-0682567;ETHYL 1-METHYL-1,2,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE

Suppliers and Price of Ethyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl 1-methyl-1,2,5,6-tetrahydronicotinate 95%
1g
$ 239.00

Crysdot
Ethyl1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate 95+%
5g
$ 628.00

Chemenu
Ethyl1-methyl-1,2,5,6-tetrahydronicotinate 95%
5g
$ 593.00

American Custom Chemicals Corporation
ETHYL-1-METHYL-1,2,5,6-TETRAHYDRONICOTINATE 95.00%
1G
$ 839.69

Alichem
Ethyl1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
1g
$ 400.00

AK Scientific
Ethyl1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
1g
$ 372.00

Total 14 raw suppliers

Chemical Property of Ethyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate

Chemical Property:

Vapor Pressure:0.072mmHg at 25°C
Boiling Point:228.8oC at 760 mmHg
PKA:7.92±0.40(Predicted)
Flash Point:86.2oC
PSA：29.54000
Density:1.038g/cm3
LogP:0.74930
Storage Temp.:2-8°C
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:169.110278721
Heavy Atom Count:12
Complexity:199

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 1-methyl-1,2,5,6-tetrahydronicotinate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CCCN(C1)C

Technology Process of Ethyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate

There total 10 articles about Ethyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 111509-87-6,129996-05-0
Ethyl 3-methyl-2-oxo-6-vinyl-3,4,5,6-tetrahydro-2H-1,3-oxazine-5-carboxylate

: 28125-84-0,5497-43-8
Homoarecoline

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 120 ℃; for 0.75h;
DOI:10.3987/COM-89-S77

Reference yield: 64.0%

: 470700-28-8
ethyl 1-methyl-3-(phenylsulfinyl)piperidine-3-carboxylate

: 56060-42-5
ethyl 1-methyl-1,4,5,6-tetrahydropyridine-3-carboxylate

: 28125-84-0,5497-43-8
Homoarecoline

Guidance literature:: With acetic acid; at 80 ℃; for 22h;
DOI:10.1002/1522-2675(200205)85:5<1399::AID-HLCA1399>3.0.CO;2-R

Reference yield:

: 71962-74-8
Ethyl nipecotate

: 28125-84-0,5497-43-8
Homoarecoline

Guidance literature:: Multi-step reaction with 4 steps

1: 42.09 g / AcOH; H₂ / Pd/C / ethanol / 20 °C

2: 52 percent / (iPr)2NH; BuLi / tetrahydrofuran

3: 6.7 g / oxone / acetone; H₂O / 0.5 h / 0 - 5 °C

4: DBU / toluene / 1 h / 110 °C

With Oxone; n-butyllithium; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetone; toluene;
DOI:10.1002/1522-2675(200205)85:5<1399::AID-HLCA1399>3.0.CO;2-R