α－Cuparenone

Base Information

• Chemical Name: α－Cuparenone
• CAS No.: 28152-91-2
• Molecular Formula: C15H20O
• Molecular Weight: 216.323
• Mol file: 28152-91-2.mol

Synonyms:(4R)-β-cuparenone;(+)-β-Cuparenone;(R)-3,3,4-Trimethyl-4-p-tolyl-cyclopentanone;β-Cuparenon;

Chemical Property of α－Cuparenone

Chemical Property:

• PSA: 17.07000
• LogP: 3.64180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α－Cuparenone

There total 21 articles about α－Cuparenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(1S,4R)-3,3,4-trimethyl-4-p-tolyl-cyclopentanol (741276-41-5,24887-33-0) → (R)-(+)-β-cuparenone (28152-91-2)

Guidance literature:

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; In dichloromethane; under 20 Torr;

DOI:10.1016/j.tet.2004.05.037

Reference yield: 86.0%

dimethyl zinc(II) (544-97-8) + (4R)-3,4-dimethyl-4-(p-tolyl)-2-cyclopentenone (109334-10-3) → (R)-(+)-β-cuparenone (28152-91-2)

Guidance literature:

bis(acetylacetonate)nickel(II); In diethyl ether; Ambient temperature;

DOI:10.1021/ja00249a066

Reference yield: 85.0%

(+)-(1R,5R)-4,4-dimethyl-5-p-tolyl-bicyclo[3.1.0]hexan-2-one (936723-38-5) → (R)-(+)-β-cuparenone (28152-91-2)

Guidance literature:

With lithium; tert-butyl alcohol; In diethyl ether; ammonia; at -78 ℃; for 0.25h;

DOI:10.1021/ja0672932

upstream raw materials:

dimethyl zinc(II)

(4R)-3,4-dimethyl-4-(p-tolyl)-2-cyclopentenone

(1S,4R)-3,3,4-trimethyl-4-p-tolyl-cyclopentanol

(+)-(1R,5R)-4,4-dimethyl-5-p-tolyl-bicyclo[3.1.0]hexan-2-one