2-hydroxyisophthalonitrile

Base Information

• Chemical Name: 2-hydroxyisophthalonitrile
• CAS No.: 28177-80-2
• Molecular Formula: C8H4N2O
• Molecular Weight: 144.133
• Mol file: 28177-80-2.mol

Synonyms:2-Hydroxyisophthalonitril;2-Hydroxy-isophthalonitril;

Chemical Property of 2-hydroxyisophthalonitrile

Chemical Property:

• Boiling Point: 293.4±30.0 °C(Predicted)
• PKA: 4.37±0.10(Predicted)
• PSA: 67.81000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 1.13556

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxyisophthalonitrile

There total 10 articles about 2-hydroxyisophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

potassium cyanide (151-50-8) + o-nitrobenzonitrile (612-24-8) → salicylonitrile (611-20-1) + 2,6-dicyanophenol (28177-80-2)

Guidance literature:

In dimethyl sulfoxide; at 100 ℃;

Reference yield: 60.0%

potassium cyanide (151-50-8) + o-nitrobenzonitrile (612-24-8) → 2,6-dicyanophenol (28177-80-2)

Guidance literature:

In dimethyl sulfoxide; at 100 - 120 ℃;

Reference yield: 56.0%

potassium cyanide (151-50-8) + Benzene-1-nitro-2,6-dicyano (51762-72-2) → 2,6-dicyanophenol (28177-80-2) + benzene-1,2,3-tricarbonitrile (38700-18-4) + 3-cyanophthalimide (773-71-7)

Guidance literature:

With sodium carbonate; Yield given. Multistep reaction; 1.) DMSO, 110 deg C, 0.5 h;

upstream raw materials:

potassium cyanide

Benzene-1-nitro-2,6-dicyano

aniline

o-nitrobenzonitrile

Downstream raw materials:

2-hydroxyisophthalic acid

5-bromo-2-hydroxyisophthalonitrile

2-hydroxy-5-iodoisophthalonitrile

bis(2,6-dicyanophenyl) ether

Refernces

• 1、 Gorvin, John H.. "Aromatic Nitro-group Displacement Reactions. Part 3. Minor Products of the o-Cyanophenol Synthesis". . p. 738 - 762. Retrieved 2007/10/02.