5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[(phenylacetyl)amino]-, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[(phenylacetyl)amino]-, (6R,7R)-
CAS No.:28240-15-5
Molecular Formula:C16H16N2O5S
Molecular Weight:348.379
Hs Code.:
Mol file:28240-15-5.mol

Synonyms:(R)-3-Hydroxymethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;

Suppliers and Price of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[(phenylacetyl)amino]-, (6R,7R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[(phenylacetyl)amino]-, (6R,7R)-

Chemical Property:

Melting Point:199 °C
Boiling Point:783.1±60.0 °C(Predicted)
PSA：132.24000
Density:1.55±0.1 g/cm3(Predicted)
LogP:0.28880

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[(phenylacetyl)amino]-, (6R,7R)-

There total 11 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[(phenylacetyl)amino]-, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 15690-38-7
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 103-80-0
phenylacetyl chloride

: 28240-15-5
3-hydroxymethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; With benzenesulfonamide; In N,N-dimethyl acetamide; at 20 ℃; for 0.5h;

phenylacetyl chloride; In N,N-dimethyl acetamide; at -20 - -10 ℃; for 1.5h;
DOI:10.1016/j.bmcl.2006.08.045

Reference yield: 67.0%

: 859-07-4
cephaloram

: 28240-15-5
3-hydroxymethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: cephaloram; With triethylamine; In methane; water; at 0 - 5 ℃; for 0.25h;

With tetra(n-butyl)ammonium hydroxide; acetic acid; In methane; water; at -18 ℃; for 7.5h; pH=5;

Reference yield: 67.0%

: 859-07-4
cefaloram

: 28240-15-5
7-[(2-phenylacetyl)amino]-3-hydroxymethyl cephalosporanic acid

Guidance literature:: cefaloram; With methane; triethylamine; In water; at 0 - 5 ℃; for 0.25h;

With tetra(n-butyl)ammonium hydroxide; In water; at -18 ℃; for 7.5h;

With acetic acid; In water; pH=5;