2-(2-Fluorophenyl)quinoline

Base Information

• Chemical Name: 2-(2-Fluorophenyl)quinoline
• CAS No.: 2836-41-1
• Molecular Formula: C15H10FN
• Molecular Weight: 223.25
• DSSTox Substance ID: DTXSID40469596
• Nikkaji Number: J3.023.714E
• Wikidata: Q82297382
• Mol file: 2836-41-1.mol

Synonyms:2-(2-fluorophenyl)quinoline;2836-41-1;quinoline,2-(2-fluorophenyl)-;SCHEMBL6087610;DTXSID40469596;ZXMOPHCBXQTALI-UHFFFAOYSA-N;SB68807

Chemical Property of 2-(2-Fluorophenyl)quinoline

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.079727485
• Heavy Atom Count: 17
• Complexity: 255

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)C3=CC=CC=C3F

Technology Process of 2-(2-Fluorophenyl)quinoline

There total 9 articles about 2-(2-Fluorophenyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Aminobenzyl alcohol (5344-90-1) + 2'-Fluoroacetophenone (445-27-2) → 2-(2-fluorophenyl)quinoline (2836-41-1)

Guidance literature:

With C₂₂H₂₄ClN₃ORu; potassium hydroxide; In toluene; at 80 ℃; for 5h; Catalytic behavior; Green chemistry;

DOI:10.1002/aoc.4582

Reference yield: 87.0%

2-Aminobenzyl alcohol (5344-90-1) + 1-(2-fluorophenyl)ethanol (445-26-1) → 2-(2-fluorophenyl)quinoline (2836-41-1)

Guidance literature:

With 9,10-phenanthrenequinone; dimethyl sulfoxide; sodium hydroxide; at 20 ℃; for 6h; Irradiation;

DOI:10.1021/acs.joc.1c01386

Reference yield: 86.0%

2-bromoquinoline (2005-43-8) + o-fluorophenylboronic acid (1993-03-9) → 2-(2-fluorophenyl)quinoline (2836-41-1)

Guidance literature:

With potassium phosphate monohydrate; (PCy₃)Pd(crotyl)Cl; FI-750-M; In water; at 45 ℃; Inert atmosphere; Micellar solution; Green chemistry;

DOI:10.1002/cctc.201800958

upstream raw materials:

2'-Fluoroacetophenone

2-nitro-benzaldehyde

2-Aminobenzyl alcohol

1-(2-fluorophenyl)ethanol

Downstream raw materials:

2-(4'-methyl-[1,1'-biphenyl]-2-yl)quinoline

Refernces

• 1、 Das, Siuli,Mondal, Rakesh,Chakraborty, Gargi,Guin, Amit Kumar,Das, Abhishek,Paul, Nanda D.. "Zinc Stabilized Azo-anion Radical in Dehydrogenative Synthesis of N-Heterocycles. An Exclusively Ligand Centered Redox Controlled Approach". . p. 7498 - 7512. Retrieved 2021/06/30.
• 2、 Di Filippo, Mara,Baumann, Marcus. "Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization-Cyclization Process". . p. 6199 - 6211. Retrieved 2020/08/26.