2-(4-Fluorophenyl)naphthalene

Base Information

• Chemical Name: 2-(4-Fluorophenyl)naphthalene
• CAS No.: 28396-55-6
• Molecular Formula: C16H11F
• Molecular Weight: 222.262
• DSSTox Substance ID: DTXSID101307696
• Nikkaji Number: J2.620.947A
• Mol file: 28396-55-6.mol

Synonyms:2-(4-fluorophenyl)naphthalene;28396-55-6;2p-fluorophenylnaphthalene;2-p-fluorophenylnaphthalene;SCHEMBL11469524;NEDUMIIWPOQJOA-UHFFFAOYSA-N;DTXSID101307696

Chemical Property of 2-(4-Fluorophenyl)naphthalene

Chemical Property:

• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 222.084478513
• Heavy Atom Count: 17
• Complexity: 242

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)C3=CC=C(C=C3)F

Technology Process of 2-(4-Fluorophenyl)naphthalene

There total 40 articles about 2-(4-Fluorophenyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromonaphthalene (580-13-2) + 4-flourophenylmagnesium bromide (352-13-6) → 2-(4-fluorophenyl)naphthalene (28396-55-6)

Guidance literature:

With lithium chloride; In tetrahydrofuran; toluene; at 110 ℃; for 48h; Inert atmosphere;

DOI:10.1246/cl.140155

Reference yield: 92.0%

4-fluorophenyl N,N-dimethylsulfamate (1259092-05-1) + naphthalene-2-boronic acid (32316-92-0) → 2-(4-fluorophenyl)naphthalene (28396-55-6)

Guidance literature:

With morpholine; C₃₁H₄₅Cl₂N₃OPd; caesium carbonate; In water; at 110 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c3ob41382a

Reference yield: 91.0%

2-bromonaphthalene (580-13-2) + 4-fluoroboronic acid (1765-93-1) → 2-(4-fluorophenyl)naphthalene (28396-55-6)

Guidance literature:

With caesium carbonate; In propan-1-ol; water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00042

upstream raw materials:

furan

3,3'-Dibrom-4,4'-difluorbiphenyl

3-(4-fluorophenyl)-1,2-dihydronaphthalene

3,3'-dibromo-[1,1'-biphenyl]-4,4'-diamine