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N-Desmethyl sorafenib

Base Information Edit
  • Chemical Name:N-Desmethyl sorafenib
  • CAS No.:284461-74-1
  • Molecular Formula:C20H14ClF3N4O3
  • Molecular Weight:450.804
  • Hs Code.:
  • UNII:N4T1W2J64C
  • DSSTox Substance ID:DTXSID101117356
  • Wikidata:Q27284553
  • Pharos Ligand ID:XQQ9H5BZM9YC
  • ChEMBL ID:CHEMBL403732
  • Mol file:284461-74-1.mol
N-Desmethyl sorafenib

Synonyms:N-Desmethyl sorafenib;284461-74-1;Sorafenib metabolite M4;BAY-439007;CHEMBL403732;N4T1W2J64C;4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide;BAY 43-9007;BAY-43-9007;n-(4-chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-carbamoyl-4-pyridyloxy)phenyl)urea;2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl) phenyl)amino)carbonyl)amino)phenoxy)-;2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-;2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-;UNII-N4T1W2J64C;SCHEMBL548133;DTXSID101117356;BDBM50375257;4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide;F77591;Q27284553;4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide?;N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{4-[2-carbamoyl-(4-pyridyloxy)]phenyl} urea;N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-{4-[2-carbamoyl-(4-pyridyloxy)]phenyl}urea;N-[4-chloro-3-(trifluoromethyl)phenyl]N'-{4-[2-carbamoyl-(4-pyridyloxy)]phenyl}urea;4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide

Suppliers and Price of N-Desmethyl sorafenib
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • N-DesmethylSorafenib
  • 1g
  • $ 1190.00
Total 10 raw suppliers
Chemical Property of N-Desmethyl sorafenib Edit
Chemical Property:
  • Boiling Point:507.0±50.0 °C(Predicted) 
  • PKA:12.90±0.70(Predicted) 
  • PSA:106.34000 
  • Density:1.513±0.06 g/cm3(Predicted) 
  • LogP:6.13530 
  • XLogP3:3.7
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:7
  • Rotatable Bond Count:5
  • Exact Mass:450.0706525
  • Heavy Atom Count:31
  • Complexity:631
Purity/Quality:

> 95% *data from raw suppliers

N-DesmethylSorafenib *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=CC(=NC=C3)C(=O)N
  • Uses N-Desmethyl Sorafenib is a metabolite of Sorafenib (S676850) and has anti-proliferative activity in human breast cancer cells.
Technology Process of N-Desmethyl sorafenib

There total 12 articles about N-Desmethyl sorafenib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
4-chloro-3-trifluoromethyl-aniline; With 1,1'-carbonyldiimidazole; In 1,1-dichloroethane; at 65 ℃; for 16h;
4-(4-aminophenoxy)-2-pyridinecarboxamide; In tetrahydrofuran; 1,1-dichloroethane; at 20 - 60 ℃; for 4h;
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