1-(4-(2-(aminomethyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Base Information

Chemical Name:1-(4-(2-(aminomethyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
CAS No.:1012059-03-8
Molecular Formula:C₂₀H₁₆ClF₃N₄O₂
Molecular Weight:436.821
Hs Code.:

Synonyms:1-(4-(2-(aminomethyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(4-(2-(aminomethyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(4-(2-(aminomethyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

There total 1 articles about 1-(4-(2-(aminomethyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

: 284461-74-1
4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-2-pyridine carboxamide

: 1012059-03-8
1-(4-(2-(aminomethyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-2-pyridine carboxamide; With borane; In tetrahydrofuran; at 100 ℃; for 6h;

With hydrogenchloride; methanol; water; In tetrahydrofuran; at 100 ℃; for 2h;

With water; sodium carbonate; pH=10;

Reference yield: 62.0%

: 3878-55-5
methyl hydrogen succinate

: 1012059-03-8
1-(4-(2-(aminomethyl)pyridin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

: methyl 4-((4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyridin-2-yl)methylamino)-4-oxobutanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trimethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;