N-(2-Methoxyphenyl)-1-(2-phenylethyl)piperidin-4-amine

Base Information

Chemical Name:N-(2-Methoxyphenyl)-1-(2-phenylethyl)piperidin-4-amine
CAS No.:28456-22-6
Molecular Formula:C₂₀H₂₆N₂O
Molecular Weight:310.439
Hs Code.:
ChEMBL ID:CHEMBL424535
DSSTox Substance ID:DTXSID80508655
Wikidata:Q82365765
Mol file:28456-22-6.mol

Synonyms:CHEMBL424535;28456-22-6;N-(2-Methoxyphenyl)-1-(2-phenylethyl)piperidin-4-amine;DTXSID80508655;BDBM50223560

Suppliers and Price of N-(2-Methoxyphenyl)-1-(2-phenylethyl)piperidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(2-Methoxyphenyl)-1-(2-phenylethyl)piperidin-4-amine

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:310.204513457
Heavy Atom Count:23
Complexity:322

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1NC2CCN(CC2)CCC3=CC=CC=C3

Technology Process of N-(2-Methoxyphenyl)-1-(2-phenylethyl)piperidin-4-amine

There total 6 articles about N-(2-Methoxyphenyl)-1-(2-phenylethyl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39742-60-4
1-(2-phenylethyl)-4-piperidinone

: 28456-22-6
N-(2-methoxyphenyl)-1-(2-phenylethyl)-4-piperidinamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) para-toluenesulfonic acid,. 2.) 4 Angstroem molecular sieve / 1.) toluene, reflux, 5 h, 2.) toluene, reflux, 8 h

2: NaBH₄ / methanol / 2 h / Heating

With sodium tetrahydroborate; 4 A molecular sieve; toluene-4-sulfonic acid; In methanol;

Reference yield:

: N-(2-Methoxy-phenyl)-N-(1-phenethyl-1,2,3,6-tetrahydro-pyridin-4-yl)-propionamide

: 28456-22-6
N-(2-methoxyphenyl)-1-(2-phenylethyl)-4-piperidinamine

Guidance literature:: With sodium tetrahydroborate; In methanol; for 2h; Heating;
DOI:10.1021/jm00139a003

Reference yield:

: 7157-34-8
N-(2-methoxyphenyl)propionamide

: 28456-22-6
N-(2-methoxyphenyl)-1-(2-phenylethyl)-4-piperidinamine

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid, molecular sieve (4A) / toluene / 13 h / Heating

2: NaBH₄ / methanol / 2 h / Heating

With sodium tetrahydroborate; 4 A molecular sieve; toluene-4-sulfonic acid; In methanol; toluene;
DOI:10.1021/jm00139a003