2-Chloro-3-phenylquinoline

Base Information

• Chemical Name: 2-Chloro-3-phenylquinoline
• CAS No.: 2859-30-5
• Molecular Formula: C15H10ClN
• Molecular Weight: 239.704
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID20401297
• Nikkaji Number: J2.772.603H
• Wikidata: Q82204372
• Mol file: 2859-30-5.mol

Synonyms:2-Chloro-3-phenylquinoline;2859-30-5;MFCD02179790;Quinoline, 2-chloro-3-phenyl-;SCHEMBL10816949;DTXSID20401297;LFARBJHRSSLIGX-UHFFFAOYSA-N;CAA85930;AKOS000320098;AB11433;CS-0450505;FT-0750406;EN300-7356554;J-017131

Chemical Property of 2-Chloro-3-phenylquinoline

Chemical Property:

• Vapor Pressure: 3.6E-05mmHg at 25°C
• Boiling Point: 364.1oC at 760 mmHg
• Flash Point: 205.5oC
• PSA: 12.89000
• Density: 1.235g/cm3
• LogP: 4.55520
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 239.0501770
• Heavy Atom Count: 17
• Complexity: 249

Purity/Quality:

98%Min ^*data from raw suppliers

2-Chloro-3-phenylquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 45-39-26

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC3=CC=CC=C3N=C2Cl

Technology Process of 2-Chloro-3-phenylquinoline

There total 17 articles about 2-Chloro-3-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-<2-(2-Phenylethynyl)phenyl>methanamide (13141-39-4) → 2-chloro-3-phenyl-quinoline (2859-30-5)

Guidance literature:

N-<2-(2-Phenylethynyl)phenyl>methanamide; With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

With tetrabutyl-ammonium chloride; In dichloromethane; at 40 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.09.096

Reference yield: 95.0%

3-phenyl-1H-quinolin-2-one (38035-81-3) → 2-chloro-3-phenyl-quinoline (2859-30-5)

Guidance literature:

With thionyl chloride; In chloroform; N,N-dimethyl-formamide; for 1h; Heating;

DOI:10.1248/cpb.35.2819

Reference yield: 77.0%

2-(2-phenylethynyl)phenyl isocyanide (247222-84-0) → 2-chloro-3-phenyl-quinoline (2859-30-5)

Guidance literature:

With tetrabutyl-ammonium chloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/ejoc.201901209

upstream raw materials:

3-phenyl-quinolin-2-ol

3-phenyl-1H-quinolin-2-one

3-phenyl-1,2,3,4-tetrahydro-2-quinolone

2,N-diphenylacetamide

Downstream raw materials:

3-Phenyl-2-piperazin-1-yl-quinoline

2-(4-Methyl-piperazin-1-yl)-3-phenyl-quinoline

2-(4-Ethyl-piperazin-1-yl)-3-phenyl-quinoline

2-[4-(3-Phenyl-quinolin-2-yl)-piperazin-1-yl]-ethanol