3-phenyl-3,4-dihydroquinolin-2(1H)-one

Base Information

• Chemical Name: 3-phenyl-3,4-dihydroquinolin-2(1H)-one
• CAS No.: 1022-66-8
• Molecular Formula: C15H13 N O
• Molecular Weight: 223.274
• Hs Code.: 2933790090
• European Community (EC) Number: 865-654-9
• DSSTox Substance ID: DTXSID80550811
• Nikkaji Number: J1.603.779F
• Mol file: 1022-66-8.mol

Synonyms:1022-66-8;3-phenyl-3,4-dihydroquinolin-2(1H)-one;3-phenyl-1,2,3,4-tetrahydroquinolin-2-one;3-PHENYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;2(1H)-Quinolinone, 3,4-dihydro-3-phenyl-, (+)-;SCHEMBL5668502;3-Phenyl-3,4-dihydrocarbostyril;DTXSID80550811;BAA02266;AKOS022346455;CS-0244063;2(1H)-Quinolinone, 3,4-dihydro-3-phenyl-;EN300-27155;G48839;Z235345513

Chemical Property of 3-phenyl-3,4-dihydroquinolin-2(1H)-one

Chemical Property:

• Melting Point: 178 °C
• Boiling Point: 407.8±44.0 °C(Predicted)
• PKA: 14.32±0.40(Predicted)
• PSA: 32.59000
• Density: 1.156±0.06 g/cm3(Predicted)
• LogP: 3.05010
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 223.099714038
• Heavy Atom Count: 17
• Complexity: 283

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-PHENYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(=O)NC2=CC=CC=C21)C3=CC=CC=C3

Technology Process of 3-phenyl-3,4-dihydroquinolin-2(1H)-one

There total 14 articles about 3-phenyl-3,4-dihydroquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(E)-2-phenyl-3-(2-nitrophenyl)propenoic acid (19319-35-8) → 3-phenyl-1,2,3,4-tetrahydro-2-quinolone (1022-66-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 6h; Ambient temperature;

DOI:10.1248/cpb.35.2819

Reference yield: 83.0%

C22H17NO3S → 3-phenyl-1,2,3,4-tetrahydro-2-quinolone (1022-66-8)

Guidance literature:

With magnesium; In tetrahydrofuran; methanol; at 20 ℃;

DOI:10.1021/acscatal.0c04786

Reference yield: 70.0%

2-phenyl-acrylic acid methyl ester (1865-29-8) + 2-nitrobenzenediazonium tetrafluoroborate (365-33-3) → 3-phenyl-1,2,3,4-tetrahydro-2-quinolone (1022-66-8)

Guidance literature:

2-phenyl-acrylic acid methyl ester; 2-nitrobenzenediazonium tetrafluoroborate; With palladium diacetate; In 1,4-dioxane; at 60 ℃; for 12h;

With hydrogen; palladium diacetate; pyrographite; In 1,4-dioxane; at 50 ℃; for 24h;

DOI:10.1002/chem.200900583

upstream raw materials:

(Z)-3-(2-nitrophenyl)-2-phenylprop-2-enoic acid

(E)-2-phenyl-3-(2-nitrophenyl)propenoic acid

carbon monoxide

(E)-2-styrylaniline

Downstream raw materials:

4-phenyl-5H-oxazolo[3,2-a]quinoline-1,2-dione

3-phenyl-1H-quinolin-2-one

2-chloro-3-phenyl-quinoline

3-Chloro-3-phenyl-3,4-dihydro-1H-quinolin-2-one