6-(2-AMINO-PHENYL)-3-METHYLSULFANYL-4 H-[1,2,4]TRIAZIN-5-ONE

Base Information

• Chemical Name: 6-(2-AMINO-PHENYL)-3-METHYLSULFANYL-4 H-[1,2,4]TRIAZIN-5-ONE
• CAS No.: 28732-13-0
• Molecular Formula: C₁₀H₁₀N₄OS
• Molecular Weight: 234.282
• Mol file: 28732-13-0.mol

Synonyms:6-(2-amino-phenyl)-3-methylsulfanyl-2H-[1,2,4]triazin-5-one;6-(2-amino-phenyl)-3-methylsulfanyl-2(4)H-[1,2,4]triazin-5-one;6-(2-Aminophenyl)-3-methylthio-1.2.4-triazin-5(2H)on;6-(2-aminophenyl)-3-methylthio-1,2,4-triazino-5(2H)-one;

Chemical Property of 6-(2-AMINO-PHENYL)-3-METHYLSULFANYL-4 H-[1,2,4]TRIAZIN-5-ONE

Chemical Property:

• PSA: 109.96000
• LogP: 1.71720

Purity/Quality:

99% ^*data from raw suppliers

6-(2-Aminophenyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(2-AMINO-PHENYL)-3-METHYLSULFANYL-4 H-[1,2,4]TRIAZIN-5-ONE

There total 5 articles about 6-(2-AMINO-PHENYL)-3-METHYLSULFANYL-4 H-[1,2,4]TRIAZIN-5-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

6-(2-Amino-phenyl)-3-mercapto-4H-[1,2,4]triazin-5-one + methyl iodide (74-88-4) → 3-methylthio-5-(2-aminophenyl)-1,2,4-triazin-5-one (28732-13-0)

Guidance literature:

With sodium ethanolate; at 65 - 70 ℃; for 0.5h;

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 3-methylthio-5-(2-aminophenyl)-1,2,4-triazin-5-one (28732-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. KOH, 2.) aq. KOH / 1.) 40 deg C, 1 h, 2.) 90 deg C - 95 deg C, 4 h

2: 83 percent / sodium ethoxide / 0.5 h / 65 - 70 °C

With potassium hydroxide; sodium ethanolate;

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 6-(2-aminophenyl)-3-methylthio-3,4-dihydro-1,2,4-triazin-5(2H)-one (28732-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KOH / 1.) H₂O, reflux, 2.) H₂O, reflux, 30 min

2: 1.) 1 h, 0 deg C, 2.) 2 h, RT

With potassium hydroxide;

upstream raw materials:

6-(2’-aminophenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one

methyl iodide

indole-2,3-dione

Downstream raw materials:

3-methylsulfanyl-6-phenyl-6,7-dihydro-benzo[d][1,2,4]triazino[6,5-f][1,3]oxazepine

6-(o-aminophenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione

7-acetyl-6-(4-chloro-phenyl)-3-methylsulfanyl-6,7-dihydro-benzo[d][1,2,4]triazino[6,5-f][1,3]oxazepine

3-(3-hydroxypropylamino)-5-methyl-5H-<1,2,4>-triazino-<5,6-b>indole