1-Piperidinecarboxylic acid, 4-[1-[[4-(2-butynyloxy)phenyl]sulfonyl]-2-(hydroxyamino)-2-oxoethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[1-[[4-(2-butynyloxy)phenyl]sulfonyl]-2-(hydroxyamino)-2-oxoethyl]-, 1,1-dimethylethyl ester
CAS No.:287392-60-3
Molecular Formula:C22H30N2O7S
Molecular Weight:466.555
Hs Code.:
Mol file:287392-60-3.mol

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[1-[[4-(2-butynyloxy)phenyl]sulfonyl]-2-(hydroxyamino)-2-oxoethyl]-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-[1-[[4-(2-butynyloxy)phenyl]sulfonyl]-2-(hydroxyamino)-2-oxoethyl]-, 1,1-dimethylethyl ester

There total 6 articles about 1-Piperidinecarboxylic acid, 4-[1-[[4-(2-butynyloxy)phenyl]sulfonyl]-2-(hydroxyamino)-2-oxoethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 287392-60-3
tert-butyl 4-[1-{[4-(2-butynyloxy)phenyl]sulfonyl}-2-(hydroxyamino)-2-oxoethyl]-1-piperidinecarboxylate

Guidance literature:

Reference yield:

: 4-[(4-but-2-ynyloxy-benzenesulfonyl)-chlorocarbonyl-methyl]-piperidine-1-carboxylic acid tert-butyl ester

: 287392-60-3
tert-butyl 4-[1-{[4-(2-butynyloxy)phenyl]sulfonyl}-2-(hydroxyamino)-2-oxoethyl]-1-piperidinecarboxylate

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In dichloromethane; acetonitrile; at 20 ℃;
DOI:10.1021/jm040086x

Reference yield:

: 287202-47-5
4-but-2-ynyloxy-benzenesulfonyl fluoride

: 287392-60-3
tert-butyl 4-[1-{[4-(2-butynyloxy)phenyl]sulfonyl}-2-(hydroxyamino)-2-oxoethyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1.5 h / -10 °C

2: 79 percent / aq. NaOH / methanol; tetrahydrofuran / 20 °C

3: (COCl)2; DMF / CH₂Cl₂ / 20 °C

4: NH₂OH*HCl; Et₃N / acetonitrile; CH₂Cl₂ / 20 °C

With sodium hydroxide; oxalyl dichloride; hydroxylamine hydrochloride; sodium hexamethyldisilazane; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm040086x