6-FORMYL-URACIL MONOHYDRATE

Base Information

• Chemical Name: 6-FORMYL-URACIL MONOHYDRATE
• CAS No.: 36327-91-0
• Molecular Formula: C5H4N2O3
• Molecular Weight: 140.098
• Hs Code.: 2933599090
• Mol file: 36327-91-0.mol

Synonyms:Orotaldehyde(8CI);2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxaldehyde;6-Formyluracil;NSC 104159;2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde;4-pyrimidinecarboxaldehyde, 1,2,3,6-tetrahydro-2,6-dioxo-;

Chemical Property of 6-FORMYL-URACIL MONOHYDRATE

Chemical Property:

• Vapor Pressure: 1.86E-07mmHg at 25°C
• Melting Point: 0°C
• Boiling Point: 0°C
• PKA: 5.63±0.10(Predicted)
• Flash Point: 0°C
• PSA: 106.18000
• Density: 1.567 g/cm³
• LogP: -1.95360
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

6-Formyluracil ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Uracil-6-carboxaldehyde monohydrate is used as pharmaceutical intermediates.

Technology Process of 6-FORMYL-URACIL MONOHYDRATE

There total 5 articles about 6-FORMYL-URACIL MONOHYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6-Methyluracil (626-48-2) → orotoaldehyde (36327-91-0)

Guidance literature:

With selenium(IV) oxide; acetic acid; Heating;

DOI:10.1081/NCN-200059790

Reference yield:

→ orotoaldehyde (36327-91-0)

Guidance literature:

With hydrogenchloride;

Reference yield:

6-diethoxymethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (16953-49-4) → orotoaldehyde (36327-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous H₂O₂; aqueous NaOH

2: Hydrolysis

With sodium hydroxide; dihydrogen peroxide;

DOI:10.1021/ja01356a057

upstream raw materials:

6-diethoxymethyl-1H-pyrimidine-2,4-dione

6-Methyluracil

6-diethoxymethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Downstream raw materials:

6-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

orotic acid

Refernces

• 1、 Rakhimov,Shul'Man,Fedunov. "Oxidation of 6-methyl-2,4-dioxypyrimidine with selenious acid". . p. 2328 - 2331. Retrieved 2011.
• 2、 -. "Tipiracil hydrochloride and synthesis method of intermediate 6-(chloromethyl)uracil". Paragraph 0080; 0081; 0082; 0083; 0084; 0085; 0086-0092. . Retrieved 2017/07/19.
• 3、 Zhao, Cen,Pelaez, Miguel,Dionysiou, Dionysios D.,Pillai, Suresh C.,Byrne, John A.,O'Shea, Kevin E.. "UV and visible light activated TiO2 photocatalysis of 6-hydroxymethyl uracil, a model compound for the potent cyanotoxin cylindrospermopsin". . p. 70 - 76. Retrieved 2014/03/21.