10147-37-2 Usage
Description
ISOPROPYLSULFONYL CHLORIDE, also known as 2-Propanesulfonyl chloride, is a clear pale yellow-greenish liquid with chemical properties that make it a versatile compound in various industries. It is primarily used as a pharmaceutical intermediate and a reactant in the synthesis of specific compounds.
Uses
Used in Pharmaceutical Industry:
ISOPROPYLSULFONYL CHLORIDE is used as a pharmaceutical intermediate for the reductive cleavage of a secondary alcohol to methylene. This is achieved by reduction of the 2-propanesulfonyl ester with lithium triethylborohydride, which is a crucial step in the synthesis of certain pharmaceutical compounds.
Used in Chemical Synthesis:
ISOPROPYLSULFONYL CHLORIDE is used as a reactant for the preparation of 1-Isopropylsulfonyl-2-amine benzimidazole. This is done through an N-sulfonylation reaction with 2-aminobenzimidazole in the presence of a base, which is essential for the development of specific chemical compounds.
Used in Synthesis of Phosphorothioate Oligonucleotide Analogs:
ISOPROPYLSULFONYL CHLORIDE is also used in the synthesis of Bis(isopropylsulfonyl)disulfide, a sulfurizing agent. This agent is crucial for the production of phosphorothioate oligonucleotide analogs, which have significant applications in the field of molecular biology and genetic research.
General Description:
The solvolysis of ISOPROPYLSULFONYL CHLORIDE by an addition-elimination (association-dissociation) pathway has been studied, providing valuable insights into its chemical behavior and potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 10147-37-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,4 and 7 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 10147-37:
(7*1)+(6*0)+(5*1)+(4*4)+(3*7)+(2*3)+(1*7)=62
62 % 10 = 2
So 10147-37-2 is a valid CAS Registry Number.
InChI:InChI=1/C3H7ClO2S/c1-3(2)7(4,5)6/h3H,1-2H3
10147-37-2Relevant articles and documents
Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4
Gómez-Palomino, Alejandro,Cornella, Josep
supporting information, p. 18235 - 18239 (2019/11/13)
Reported here is a simple and practical functionalization of primary sulfonamides, by means of a pyrylium salt (Pyry-BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Because of the variety of primary sulfonamides in pharmaceutical contexts, special attention has been focused on the direct conversion of densely functionalized primary sulfonamides by a late-stage formation of the corresponding sulfonyl chloride. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides, sulfonates, sulfides, sulfonyl fluorides, and sulfonic acids. The mild reaction conditions and the high selectivity of Pyry-BF4 towards NH2 groups permit the formation of sulfonyl chlorides in a late-stage fashion, tolerating a preponderance of sensitive functionalities.
An easy microwave-assisted synthesis of sulfonamides directly from sulfonic acids
De Luca, Lidia,Giacomelli, Giampaolo
, p. 3967 - 3969 (2008/09/19)
(Chemical Equation Presented) An easy and handy synthesis of sulfonamides directly from sulfonic acids or its sodium salts is reported. The reaction is performed under microwave irradiation, has shown a good functional group tolerance, and is high yielding.
N-substituted sulfonamide derivatives
-
, (2008/06/13)
The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
