63197-61-5 Usage
Uses
Used in Pharmaceutical Industry:
2-amino-6-benzoyl-1-[(isopropyl)sulphonyl]-1H-benzimidazole is used as an intermediate in the synthesis of Zinviroxime (Z465300), which is the (Z)-isomer of Enviroxime (E559600). Zinviroxime is a benzimidazole derivative that serves as an antiviral agent, specifically targeting the inhibition of rhinovirus multiplication. This makes it a valuable compound in the development of treatments for viral infections, particularly those caused by rhinoviruses.
In the synthesis process, 2-amino-6-benzoyl-1-[(isopropyl)sulphonyl]-1H-benzimidazole acts as a key building block, contributing to the overall structure and activity of the final product, Zinviroxime. Its role in the pharmaceutical industry highlights the importance of understanding and utilizing the properties of complex organic compounds in drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 63197-61-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,1,9 and 7 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 63197-61:
(7*6)+(6*3)+(5*1)+(4*9)+(3*7)+(2*6)+(1*1)=135
135 % 10 = 5
So 63197-61-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H17N3O3S/c1-11(2)24(22,23)20-15-10-13(8-9-14(15)19-17(20)18)16(21)12-6-4-3-5-7-12/h3-11H,1-2H3,(H2,18,19)
63197-61-5Relevant academic research and scientific papers
Wikel, J. H.,Paget, C. J.,DeLong, D. C.,Nelson, J. D.,Wu, C. Y. E.,et al.
, p. 368 - 372 (1980)
The synthesis and antirhinovirus activity of syn and anti isomers of 6-methyl>-1--1H-benzimidazol-2-amine (4 and 5) are reported.The structural assignements of 4 and 5 are based upon 13C NMR spectra of both isomers and also X-ray analysis of 5.The anti-isomer 5 was more potent than the syn-isomer 4 when compared as an inhibitor of rhinovirus multiplication in vitro.Both isomers inhibited multiplication of 15 differrent serotypes of rhinovirus.
4-Nitrobenzophenone compounds
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, (2008/06/13)
A compound of the formula I STR1 and other compounds and process for preparing, which compounds are useful as intermediates.
Carbonyl-substituted 1-sulfonylbenzimidazoles
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, (2008/06/13)
Certain carbonyl-substituted-1-sulfonylbenzimidazole compounds are useful as antiviral agents.
