104579-02-4 Usage
Description
N4-BENZOYL-5-METHYLDEOXYCYTIDINE, also known as tazemetostat, is a synthetic chemical compound with significant potential in cancer treatment. It functions as a potent and selective inhibitor of the EZH2 enzyme, which plays a crucial role in gene expression regulation. Tazemetostat has demonstrated effectiveness in curbing the proliferation of cancer cells, especially in specific lymphomas and solid tumors. Its ongoing clinical trials are exploring its potential in treating a variety of cancers, with early findings indicating promising anti-tumor capabilities. Tazemetostat is emerging as a novel and valuable asset in combating cancer.
Uses
Used in Oncology:
N4-BENZOYL-5-METHYLDEOXYCYTIDINE is used as an anticancer agent for its ability to inhibit the EZH2 enzyme, which is often dysregulated in cancer cells. This inhibition helps in controlling the growth and proliferation of cancer cells, particularly in lymphomas and solid tumors.
Used in Clinical Trials:
N4-BENZOYL-5-METHYLDEOXYCYTIDINE is used as a subject of investigation in clinical trials to assess its safety, efficacy, and optimal dosages for the treatment of various types of cancer, with the aim of advancing its application in oncology.
Used in Drug Development:
N4-BENZOYL-5-METHYLDEOXYCYTIDINE is utilized in the development of new cancer therapeutics, representing a novel approach to targeting the EZH2 enzyme and potentially offering new treatment options for patients with cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 104579-02-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,5,7 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 104579-02:
(8*1)+(7*0)+(6*4)+(5*5)+(4*7)+(3*9)+(2*0)+(1*2)=114
114 % 10 = 4
So 104579-02-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H19N3O5/c1-10-8-20(14-7-12(22)13(9-21)25-14)17(24)19-15(10)18-16(23)11-5-3-2-4-6-11/h2-6,8,12-14,21-22H,7,9H2,1H3,(H,18,19,23,24)/t12-,13+,14+/m0/s1
104579-02-4Relevant articles and documents
Unexpected shift to a 4-imino tautomer upon N4-acylation of 5- methylcytosin-1-yl nucleoside analogues
Busson,Kerremans,Van Aerschot,Peeters,Blaton,Herdewijn
, p. 1079 - 1082 (1999)
In contrast with the behaviour of 5-unsubstituted cytosine nucleoside analogues, 5-methylcytosine derivatives show upon N4-benzoylation, commonly used as base protection in oligonucleotide synthesis, a tautomeric change of the base moiety from a 4-amino- into a 4-imino isomer. In the latter form, which is easily diagnosticized by 13C NMR and confirmed by X-ray data, the compounds seem to be hydrolytically less stable.
