105259-40-3Relevant articles and documents
Novel N-ferrocenylmethyl, N′-methyl-2-substituted benzimidazolium iodide salts with in vitro activity against the P. falciparum malarial parasite strain NF54
Howarth, Joshua,Hanlon, Keith
, p. 751 - 754 (2001)
Herein we disclose results of our research into a novel class of benzimidazolium compounds active against malarial parasites. We have discovered that N-ferrocenylmethyl, N′-methyl-2-aryl (or styryl) benzimidazolium iodide salts show excellent in vitro activity against the P. falciparum malarial parasite strain NF54.
Reaction of imidazoles with allyltributyltin in the presence of chloroformate
Itoh, Takashi,Hasegawa, Hiroshi,Nagata, Kazuhiro,Okada, Mamiko,Ohsawa, Akio
, p. 5399 - 5402 (1992)
The reaction of imidazoles with allyltributyltin in the presence of chloroformate gave 2-allyl-1,3-dialkoxycarbonyl-4-imidazolines in good yields. The addition products were aromatized with potassium ferricyanide under basic condition to afford corresponding 2-allylimidazoles.
Allylation of Azoles with Allyltributyltin via Unstable N-(Alkoxycarbonyl)azolium Salts
Itoh, Takashi,Hasegawa, Hiroshi,Nagata, Kazuhiro,Ohsawa, Akio
, p. 1319 - 1325 (2007/10/02)
The one-pot reactions of imidazoles with allyltributyltin in the presence of alkyl chloroformates gave 2-allyl-1,3-bis(alkoxycarbonyl)-4-imidazolines in good yields.The reactions of thiazoles and oxazoles also proceeded in a similar manner.The instability of the intermediary quaternary salts required the nucleophiles to be added simultaneously with the chloroformate.Therefore, the reaction was specific for allyltributyltin, since it doesn't react with the carbonyl group of chloroformates.The dihydro allyl adducts thus obtained were aromatized with potassium ferricyanide under basic conditions to afford the corresponding 2-allylazoles.
