105307-66-2

• 

• Basic information

  1. Product Name: N-(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
  2. Synonyms: 2H-1,3,2-oxazaphosphorin-2-amine, N-(2-chloroethyl)tetrahydro-, 2-oxide
  3. CAS NO:105307-66-2
  4. Molecular Formula: C₅H₁₂ClN₂O₂P
  5. Molecular Weight: 198.5877
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 105307-66-2.mol
  9. Article Data: 6

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 272.1°C at 760 mmHg
  3. Flash Point: 118.4°C
  4. Appearance: N/A
  5. Density: 1.3g/cm³
  6. Vapor Pressure: 0.0062mmHg at 25°C
  7. Refractive Index: 1.486
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: N-(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide(CAS DataBase Reference)
  11. NIST Chemistry Reference: N-(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide(105307-66-2)
  12. EPA Substance Registry System: N-(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide(105307-66-2)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 105307-66-2(Hazardous Substances Data)

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105307-66-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 105307-66-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,3,0 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 105307-66:
(8*1)+(7*0)+(6*5)+(5*3)+(4*0)+(3*7)+(2*6)+(1*6)=92
92 % 10 = 2
So 105307-66-2 is a valid CAS Registry Number.

105307-66-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name	N-(2-Chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105307-66-2 SDS

105307-66-2Upstream product

• 119670-13-2 3-chloroacetyltetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide 
• 870-24-6 2-chloroethanamine hydrochloride 
• 5638-58-4 2-chloro-2-oxo-1,3,2λ⁵-oxazaphosphinane 
• 72578-61-1 (R)-2-aziridin-1-yl-3-((R)-1-phenyl-ethyl)-[1,3,2]oxazaphosphinane 2-oxide 
• 50-18-0 cyclophosphamide 
• 156-87-6 propan-1-ol-3-amine 
• 72578-67-7 (2-chloro-ethyl)-[(R)-2-oxo-3-((R)-1-phenyl-ethyl)-2λ⁵-[1,3,2]oxazaphosphinan-2-yl]-amine 
• 72578-68-8 (2-chloro-ethyl)-[(S)-2-oxo-3-((R)-1-phenyl-ethyl)-2λ⁵-[1,3,2]oxazaphosphinan-2-yl]-amine 

105307-66-2Downstream Products

• 72578-71-3 3-chloroacetyl-2-(2-chloro-ethylamino)-[1,3,2]oxazaphosphinane (R)-2-oxide 

105307-66-2Relevant articles and documents

Formation of 4 ketocyclophosphamide by the oxidation of cyclophosphamide with KMnO4

Jarman

, p. 812 - 814 (1973)

-

Synthetic method of cyclophosphamide

-

Paragraph 0012-0014, (2019/10/08)

The invention relates to the technical field of cyclophosphamide, in particular to a synthetic method of cyclophosphamide. The defects of low yield and high cost existing in the prior art are solved. The synthetic method includes the following methods: S1: simultaneously adding 3-aminopropanol and triethylamine into a phosphorus oxychloride solution and obtaining 2-chlorotetrahydro-2H-1,3,2-oxynitrogen phosphorus heterocyclohexene-2-oxide through mixing; S2: reacting 2-chlorotetrahydro-2H-1,3,2-oxynitrogen phosphorus heterocyclohexene-2-oxide with 2-chloroethylamine hydrochloride to obtain 2-[(2-chlormethine)amidogen]tetrahydrogen-2H-1,3,2-oxynitrogen phosphorus heterocyclohexene-2-oxide; simultaneously adding 3-aminopropanol and triethylamine into the phosphorus oxychloride solution, reversing an original preparation process, improving yield; and adding sodium borohydride/concentrated sulfuric acid into 3-(2-chloracetyl group)-2-[(2-chlormethine)amidogen]tetrahydrogen-2H-1,3,2-oxynitrogen phosphorus heterocyclohexene-2-oxide. Thus, yield value of the step is improved and the total yield is further improved.

Analysis of the urinary excretion of ifosfamide and its N-dechloroethylated metabolites in children using 31P-NMR spectroscopy

Misiura, Konrad,Zubowska, Malgorzata,Zielinska, Elzbieta

, p. 372 - 377 (2007/10/03)

Amounts of ifosfamide (GAS 3778-73-2) and its N-dechloroethylated metabolites excreted in the urine were measured using 31P-NMR spectroscopy in 26 cancer children treated with this drug. Strong inter-patient variation in levels of these compoun

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