111550-46-0Relevant articles and documents
Synthesis of novel chiral Schiff-base ligands and their application in asymmetric nitro aldol (Henry) reaction
Colak, Mehmet,Aral, Tarik,Hosgoeren, Halil,Demirel, Nadir
, p. 1129 - 1133 (2007)
Chiral Schiff-bases prepared from chiral amino alcohols catalyze the enantioselective Henry (nitro aldol) reaction between nitromethane and p-nitrobenzaldehyde in the presence of Cu(OTf)2 and Zn(OTf)2. Zn(OTf)2 promoted the reaction yield, while Cu(OTf)2 promoted the enantiomeric excess. The highest enantioselectivities were observed with ligand 3 (44% ee) and ligand 5 (47% ee).
Synthesis and spectral properties of new ethylene glycol bridged oxazol-5-ones: High Stokes’ shift fluorophores sensitive to solvent polarity
Ozturk Urut, Gulsiye,Bayramin, Dilek,Alp, Serap
, p. 109 - 115 (2017)
A set of new oxazol-5-one fluorophores incorporating ethylene glycol chains terminated with an aldehyde unit has been synthesized and characterized structurally. Two pairs of compounds can be distinguished according to the substitution on the oxazol-5-one moiety: one pair bears a tolyl unit and the other a nitrophenyl unit. The difference within the pairs is the length of the ethylene glycol chain. The evaluation of absorption and emission properties of the new oxazol-5-one derivatives was carried out in seven different solvents of varying polarity, which showed intense absorption maxima at 384–418 nm and emission maxima at 430–607 nm, respectively. The solvatofluorism study of 3a and 3c revealed that their emission wavelengths are very sensitive to solvent polarity and are red shifted in polar solvents. 3a and 3c fluorophores exhibited high Stokes shift values between 4158 and 7921 cm? 1.
Organocatalyzed step-growth polymerization through desymmetrization of cyclic anhydrides: Synthesis of chiral polyesters
Martin, Anthony,Robert, Frédéric,Taton, Daniel,Cramail, Henri,Vincent, Jean-Marc,Landais, Yannick
, p. 11946 - 11953 (2014)
The polymerization of prochiral bis-anhydrides with diols catalyzed by a cinchona alkaloid was shown to provide chiral polyesters in good yields and with high levels of stereocontrol. The structures of the polyesters were determined by 1H and
Biological evaluation of bisbenzaldehydes against four Mycobacterium species
Cappoen, Davie,Forge, Delphine,Vercammen, Frank,Mathys, Vanessa,Kiass, Mehdi,Roupie, Virginie,Anthonissen, Roel,Verschaeve, Luc,Vanden Eynde, Jean Jacques,Huygen, Kris
, p. 731 - 738 (2013/07/25)
A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.
