116414-91-6Relevant articles and documents
PROCESS FOR PREPARATION OF NOVEL ANDROGEN RECEPTOR ANTAGONIST
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Page/Page column 20; 28, (2018/07/05)
A process for the preparation of a novel androgen receptor antagonist is provided, comprising essentially conducting cyclization reaction of a compound of formula V to obtain a compound of formula VI. This method has the advantages of easily obtainable starting material, high atomic utilization rate, mild reaction conditions, and simply post-treatment. In addition, ODM-201 and its single isomers can be synthesized directionally by controlling the stereochemistry of starting material, with the advantages of simple and controllable process and suitability for industrial production.