118664-05-4Relevant articles and documents
CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
Bard, Jonathan A.,Brown, Christopher J.,Chen, Xuemei,Clark-Frew, Daniel,Coe, Samuel,Conlon, Mike,Davis, Randall,Dominguez, Celia,Ensor, Samantha,Esposito, Simone,Gai, Xinjie,Green, Samantha,Greenaway, Catherine,Haber, James,Halldin, Christer,Hayes, Sarah,He?mann, Manuela,Herbst, Todd,Herrmann, Frank,Hsai, Ming Min,Johnson, Peter D.,Khetarpal, Vinod,Kotey, Adrian,Lee, Matthew R.,Liu, Longbin,Mangette, John E.,Mills, Matthew R.,Monteagudo, Edith,Moren, Anton Forsberg,Mrzljak, Ladislav,Munoz-Sanjuan, Ignacio,Nag, Sangram,Nibbio, Martina,Orsatti, Laura,Prime, Michael E.,Schaertl, Sabine,Scheich, Christoph,Sproston, Joanne,Stepanov, Vladimir,Varn?s, Katarina,Varrone, Andrea,Wityak, John
, p. 12003 - 12021 (2021/09/02)
The expanded polyglutamine-containing mutant huntingtin (mHTT) protein is implicated in neuronal degeneration of medium spiny neurons in Huntington's disease (HD) for which multiple therapeutic approaches are currently being evaluated to eliminate or redu